Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

System of Memory01:23

System of Memory

7.5K
Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
7.5K
Working Memory01:24

Working Memory

927
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
927
Noncompartmental Analysis: Mean Residence Time01:05

Noncompartmental Analysis: Mean Residence Time

619
According to statistical moment theory, mean residence time (MRT) is an important measure in pharmacokinetics. MRT can be defined as the expected mean of a probability density function distribution. It provides valuable insights into drug disposition in the body.
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
619
Long-Term Memory01:18

Long-Term Memory

701
Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
701
Traumatic Memory01:20

Traumatic Memory

593
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
593
Repressed Memory01:16

Repressed Memory

529
Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
529

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planus.

bioRxiv : the preprint server for biology·2026
Same author

Lymphatic egress recycles tumor-experienced effector CD8 T cells to sustain immune surveillance.

bioRxiv : the preprint server for biology·2026
Same author

Deletion of low-essentiality, secretion-associated genes enhances recombinant protein production in Komagataella phaffii.

Microbial cell factories·2026
Same author

Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics.

Science (New York, N.Y.)·2026
Same author

Pichia-CLM: A language model-based codon optimization pipeline for <i>Komagataella phaffii</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The CD8 immgenT framework as a universal reference of mouse CD8αβ T cell differentiation states.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Feb 13, 2026

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
09:47

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Published on: June 17, 2016

8.7K

淋巴结居民记忆T细胞通过逃避肺部居民记忆功能障碍来保持效应能力.

Taylor A Heim, Zachary J Rogers, Sarah Duquette

    bioRxiv : the preprint server for biology
    |February 12, 2026
    PubMed
    概括
    此摘要是机器生成的。

    淋巴结 (LNRM) 中的居住记忆T细胞 (TRM) 是一个独特的群体. 与肺TRM不同,LNRM有细胞毒性,并且在人类淋巴结中普遍存在.

    更多相关视频

    A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
    09:42

    A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

    Published on: June 7, 2017

    12.0K
    Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node
    08:43

    Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node

    Published on: May 7, 2021

    5.2K

    相关实验视频

    Last Updated: Feb 13, 2026

    Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
    09:47

    Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

    Published on: June 17, 2016

    8.7K
    A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
    09:42

    A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

    Published on: June 7, 2017

    12.0K
    Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node
    08:43

    Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node

    Published on: May 7, 2021

    5.2K

    科学领域:

    • 免疫学 免疫学 免疫学
    • 细胞生物学 细胞生物学
    • 系统生物学 系统生物学

    背景情况:

    • 记忆T细胞对于适应性免疫至关重要,具有不同的子集,如居民记忆T细胞 (TRM) 和中央记忆T细胞 (TCM).
    • 通常在屏障组织中发现TRM,但它们在淋巴结中的存在和功能 (LNRM) 了解较少.
    • 了解LNRM异质性是解读局部免疫和免疫监测的关键.

    研究的目的:

    • 研究淋巴结内常存T细胞的形成,特征和功能差异 (LNRM).
    • 将LNRM与肺中的记忆T细胞 (肺RM) 和循环的中央记忆T细胞 (TCM) 进行比较.
    • 确定分化这些记忆T细胞子集的分子机制.

    主要方法:

    • 纵向抗体标记,以跟踪流感感染后的记忆T细胞迁移.
    • T细胞子集的表观遗传和转录概况 (包括染色质可访问性).
    • 对转录因子和基因表达的监管网络分析.

    主要成果:

    • CD69+CD103+ T 细胞被确定为位于淋巴结内的T 细胞,分布在各种隔间.
    • LNRM表现出一种独特的表观遗传和转录特征,准备用于细胞毒性,与肺RM形成鲜明对比,其显示了疲劳标记.
    • 与肺RM相比,LNRM在抗原重新遇到时表现出优越的增殖,细胞毒性和IFNγ产生能力.
    • 发现LNRM是人类胸部淋巴结中占主导地位的记忆T细胞子集.

    结论:

    • 淋巴结居民记忆T细胞 (LNRM) 代表了一个独特而持久的免疫细胞群.
    • LNRM具有独特的功能性质,具有循环和组织内存细胞的桥梁特性.
    • 这些发现揭示了TRM群体内的显著功能异质性,并突出了LNRM在免疫监测和反应中的重要性.