冠状动脉的特定年龄和性别分布和参考值在一个大型无症状的日本队列中
Hidenobu Takagi1,2, Masaharu Hirano3, Takashi Asano4
1Department of Advanced Radiological Imaging Collaborative Research Tohoku University Sendai Japan.
Journal of the American Heart Association
|February 12, 2026
概括
这项研究为日本成年人建立了关键的年龄和性别特定的冠状动脉 (CAC) 参考值. 这些发现凸显了在日本CAC评分中使用西方衍生的值是不合适的.
科学领域:
- 心血管成像 - 心血管成像
- 公共卫生 公共卫生
- 医学统计 医学统计
背景情况:
- 冠状动脉 (CAC) 评分对于心血管风险分层至关重要.
- 在日本缺乏现有的CAC参考数据,阻碍了准确的临床应用.
- 由于种族差异,西方衍生的CAC值不适合日本人口.
研究的目的:
- 为健康的日本人口建立第一个全面的,特定于年龄和性别的冠状动脉参考值.
- 为日本提供适当的CAC评分和风险分层的基础.
主要方法:
- 对4891名无症状的日本成年人的回顾性分析.
- 数据包括没有动脉样硬化心血管疾病或糖尿病病史的个人.
- 使用非参数回归建模来生成特定于年龄和性别的CAC百分位曲线.
主要成果:
- 男性的CAC负担比女性高,男性的CAC负担比女性高,男性的CAC负担比女性高,男性的CAC负担比女性高,男性的CAC负担比女性高.
- 在男性 (曲向下) 和女性 (曲向上) 之间,CAC进展模式不同.
- 在多民族动脉样硬化研究 (MESA) 数据中,与白人参与者相比,日本队列的CAC负担明显较低.
结论:
- 这项研究为健康的日本人口提供了第一个大规模,年龄和性别特定的CAC参考值.
- 开发的百分位曲线是临床医生评估患者CAC负担相对于同龄人的实际工具.
- 在日本,利用特定人口的门值对于准确的心血管风险分层至关重要.
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