批准的共识驱动的流行病学截止值用于水生Vibrio harveyi分离物的标准微稀释抗菌敏感性测试
Charles M Gieseker1, David A Simon2, Destini Coiner2
1Center for Veterinary Medicine, US Food & Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
Diseases of aquatic organisms
|February 12, 2026
概括
针对Vibrio harveyi抗菌感应性测试 (AST) 建立了新的流行病学截止值 (ECV). 这些标准有助于监测水产养殖病原体的抗微生物耐药性.
科学领域:
- 兽医微生物学 兽医微生物学
- 水生动物卫生 水生动物卫生
- 抗微生物药物耐药性的监测和监测
背景情况:
- 可靠的抗微生物敏感性测试 (AST) 对于管理水产养殖中的抗微生物使用至关重要.
- 对于像Vibrio harveyi这样的水生病原体,存在标准化的AST方法,但缺乏解释标准 (流行病学值 - ECV).
- 对于区分易感细菌和对抗微生物药物的敏感性降低的细菌来说,ECV是必不可少的.
研究的目的:
- 为了确定流行病学截止值 (ECV),用于解释Vibrio harveyi的抗菌感应性测试 (AST) 结果.
- 支持耐药性监测,指导水产养殖中的抗菌疗法决策.
- 在监测V. harveyi抗菌素敏感性的国际努力中协调一致.
主要方法:
- 在三个独立实验室中使用CLSI标准微稀释方法生成最小抑制度 (MIC) 数据.
- 测试了76种V. harveyi分离物在28°C下对9种抗微生物药物进行24-28小时的测试.
- 在与CLSI工作组合作的情况下,分析了MIC数据与标准化电阻解释 (NRI) 和ECOFFinder程序的结合,以计算潜在的ECV.
主要成果:
- 六种主要抗微生物的已确定的和拟议的ECV:恩罗夫洛克萨 (≤1微克/毫升),佛罗芬尼科尔 (≤2微克/毫升),甘他 (≤4微克/毫升),氧林酸 (≤1微克/毫升),氧化 (≤1微克/毫升) 和三甲/硫甲 (≤0.5/9.5微克/毫升).
- 这些拟议的ECV被CLSI的兽医抗菌素敏感性测试小组委员会接受.
- 已批准的ECV将被纳入下一版的CLSI VET04补充.
结论:
- 新批准的ECV为V. harveyi AST.提供了重要的解释标准.
- 这些ECV的实施将提高水产养殖中抗菌素耐药性监测的准确性和一致性.
- 这些标准将促进明智的治疗决策,并促进在鱼类健康管理中明智使用抗微生物药物.
关键词:
流行病学界限值是指流行病学界限值.鱼类 鱼类 鱼类 鱼类 鱼类在MIC中,MIC是MIC,MIC是MIC.最低抑制度的最小抑制度标准的MIC测试是标准的MIC测试这种病毒是Vibrio harveyi.更多相关视频
12:39Antimicrobial Susceptibility Testing of Mycobacterium Tuberculosis Complex for First and Second Line Drugs by Broth Dilution in a Microtiter Plate Format
Published on: June 24, 2011
38.9K
12:08Rapid Antimicrobial Susceptibility Testing by Stimulated Raman Scattering Imaging of Deuterium Incorporation in a Single Bacterium
Published on: February 14, 2022
3.4K
相关概念视频
01:26FDA Approved Drugs: Changes to Approved Drugs
275
Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
275
01:19Testing a Claim about Standard Deviation
3.0K
A complete procedure to test a claim about population standard deviation or population variance is explained here.
The hypothesis testing for the claim of population standard deviation (or variance) requires the data and samples to be random and unbiased. The population distribution also must be normal. There is no specific requirement on the sample size as the estimation is based on the chi-square distribution.
As a first step, the hypothesis (null and alternative) concerning the claim about...
The hypothesis testing for the claim of population standard deviation (or variance) requires the data and samples to be random and unbiased. The population distribution also must be normal. There is no specific requirement on the sample size as the estimation is based on the chi-square distribution.
As a first step, the hypothesis (null and alternative) concerning the claim about...
3.0K
01:24Biodiversity and Human Values
17.2K
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
17.2K
01:29Professional Values
10.8K
Nurses are responsible for caring for patients during birth, death, illness, and healing. Professional values guide the decisions and actions that nurses make in their careers. If nurses know the decisions and actions to take, providing patients with exceptional care is possible.
The values that are the foundation of the nursing profession are altruism, autonomy, human dignity, and social justice.
First, altruism refers to the concern for the welfare and well-being of others without personal...
The values that are the foundation of the nursing profession are altruism, autonomy, human dignity, and social justice.
First, altruism refers to the concern for the welfare and well-being of others without personal...
10.8K
01:31Critical Values
10.4K
A critical value is a definite value obtained from a particular probability distribution at a predecided confidence level (or a predecided significance level) for a given population parameter. The critical value provides demarcation that separates the sample statistics that are likely to occur from the ones that are unlikely to occur based on the given probability distribution and the population parameter to be estimated. The critical value for normal distribution is obtained from the z...
10.4K
01:26Introduction to Epidemiology
1.9K
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
1.9K