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Updated: Feb 13, 2026

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一个前性研究,关于孕期感知压力和流产率的前性研究
Amelia K Wesselink1, Ruth J Geller1, Sharonda M Lovett1
1Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Human reproduction (Oxford, England)
|February 12, 2026
概括
在怀孕早期感知到的压力,而不是预先怀孕,与更高的流产风险有关. 在怀孕早期减少压力的干预措施可能有助于预防流产.
科学领域:
- 生殖健康 生殖健康
- 怀孕中的心理社会因素
- 围产期流行病学 围产期流行病学
背景情况:
- 以前的研究表明,压力和流产风险之间存在联系,但研究往往存在诸如回顾性设计或专注于职业压力等局限性.
- 在先前的研究中对流产的不充分确定也阻碍了对压力-流产关系的清晰理解.
研究的目的:
- 调查预孕和早期怀孕期间感知到的压力与流产发生率之间的联系.
主要方法:
- 前性队列研究 (在线妊娠研究 - PRESTO) 涉及21-45岁的参与者试图怀孕.
- 在妊娠前期和早期怀孕期间使用感知压力量表 (PSS-10) 测量感知压力.
- 考克斯的比例危险回归模型用于分析基于PSS-10分数的流产发生率,以混因子进行调整.
主要成果:
- 在孕前感知压力 (女性或男性伴侣) 和流产发生率之间没有发现显著的关联.
- 在怀孕早期 (妊娠5-8周) 感知到的压力与更高的流产发生率密切相关.
- 早期怀孕压力和流产风险之间的关联随着PSS-10得分的提高而增加,在妊娠第7周左右达到顶峰.
结论:
- 在怀孕早期感知到的压力,但不是预先怀孕,与流产风险增加有关.
- 研究结果表明,早期怀孕期间减轻压力干预措施对预防流产有潜在的益处.
- 由于潜在的局限性,如反向因果关系和未测量的混,需要通过随机对照试验进一步确认.
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