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Updated: Feb 13, 2026

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中性粒细胞衍生反应性氧物种介导多克索鲁比诱导的心脏毒性和骨肌肉病变
Kasia Dzierlega1, Amro M Soliman1,2, Huachen Chen3
1Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.
American journal of physiology. Heart and circulatory physiology
|February 12, 2026
概括
多克索鲁比化疗会通过中性粒细胞引起肌肉损伤. 阻止这些免疫细胞或它们的活性氧物种 (ROS) 生产可以防止这种化疗副作用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 肌肉生理学 肌肉生理学
背景情况:
- 多克索鲁比 (DOX) 是一种重要的化疗药物.
- DOX具有狭窄的治疗指数,导致显著的肌肉缩和功能障碍.
- DOX诱导肌肉病变的机制,特别是炎症细胞的作用,需要进一步阐明.
研究的目的:
- 调查中性粒细胞在多克索鲁比诱导的心脏毒性和骨肌肉病变中的作用.
- 描述中性粒细胞动态及其对DOX介导的肌肉病理的贡献.
- 为了确定负责DOX诱导肌肉损伤的特定中性粒细胞衍生因素.
主要方法:
- 小鼠接受了多克索鲁比 (DOX) 的治疗.
- 在心脏,脏和肌肉组织中分析了中性粒细胞种群.
- 使用抗Ly6G抗体消耗了中性粒细胞.
- 评估了反应性氧物种 (ROS) 生产和NOX2酶.
主要成果:
- DOX的使用导致中性粒细胞在心脏,脏和肌肉中的扩张.
- 中性粒细胞的消耗显著改善了DOX诱导的心肌缩和功能障碍.
- 来自中性粒细胞的ROS,特别是通过NOX2,被确定为DOX诱导肌病的关键媒介.
结论:
- 中性粒细胞在调解多克索鲁比对心脏和骨肌肉的有害影响方面发挥着关键作用.
- 中性粒细胞衍生反应性氧物种 (ROS) 在驱动DOX诱导的心脏毒性和肌肉病症中起着关键作用.
- 向中性粒细胞-ROS通路可能提供一种策略,以减轻化疗诱导的肌肉损伤.
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