瑞典中风前后COVID-19患者中抗血栓治疗启动趋势 - 一个中断的时间序列研究
Salar Mousa1,2, Katarina Persson1, Maria Palmetun-Ekbäck1,2
1School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Basic & clinical pharmacology & toxicology
|February 12, 2026
概括
在中风后,COVID-19大流行并没有改变整体抗血栓剂的使用. 然而,抗血小板启动短暂上升,而华法林,达比加特兰和XA因子抑制剂的使用在大流行后发生了转变.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗血栓治疗对于中风管理和护理评估至关重要.
- 关于流行病对中风后抗血栓使用的影响的数据有限.
研究的目的:
- 评估COVID-19流行病对瑞典中风患者开始使用抗血栓剂的影响.
- 分析疫情爆发前后抗血栓药物启动的趋势.
主要方法:
- 全国范围的瑞典健康登记册被用于数据.
- 使用通用线性模型进行中断时间序列分析 (ITSA).
- 评估了2019年1月至2024年4月抗血栓剂启动的每月趋势,将2020年3月作为干预点.
主要成果:
- 观察到每月显著下降107例中风病例.
- 总体而言,抗血栓启动没有显著的变化.
- 抗血小板药物显示出大流行前的上升趋势,在流行后立即增加,随后下降. 干预后XA因子抑制剂的使用增加,而华法林和达比加特兰的使用减少.
结论:
- COVID-19大流行没有影响中风后的抗血栓剂的整体启动.
- 观察到抗血小板启动的短期增加.
- 在大流行爆发后,华法林,达比加特兰和XA因子抑制剂的启动发生了长期转变.
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