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Updated: May 12, 2026

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

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在巴雷特食道监测中使用生物标志物

Annesha Chatterjee¹, Julian A Abrams², Matthew D Stachler¹

¹Department of Pathology and Laboratory Medicine, University of California San Francisco, San Francisco CA 94143.

The American journal of gastroenterology

|February 12, 2026

概括

巴雷特食道患者需要更好地评估食道癌症进展的风险. 生物标志物如p53,基因组含量和甲基化DNA在识别高风险个体方面表现有前途,克服了成形障碍评估的局限性.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
分子诊断学分子诊断学

背景情况:

巴雷特食道 (Barrett's esophagus,BE) 是食道腺癌的前体,但大多数患者没有进展.
目前的风险分层依赖于失生症评估,失生症在观察者之间存在显著的变化.
迫切需要可靠的生物标志物来识别具有癌症进展高风险的BE患者.

研究的目的:

审查有希望的生物标志物来预测巴雷特食道中进展风险.
突出目前临床实践中失育症评估的局限性.
要总结关于p53的研究,异常的基因组含量和甲基化DNA标记物.

主要方法:

对调查巴雷特食道进展的生物标志物的研究进行审查.
专注于分子标记物,包括p53蛋白表达.
分析基因组不稳定性和DNA甲基化模式作为预测标记.

主要成果:

在BE中,p53异常显示出作为增加癌症风险的标志物的潜力.
异常的基因组含量 (无积分体) 与更高的进展率有关.
甲基化DNA标记物正在成为食道腺癌发展的有希望的预测因素.

结论:

生物标志物如p53,基因组含量和甲基化DNA为BE患者提供了改善的风险分层.
这些分子标记物可能可以克服失生症分级的主观性.
这些生物标志物的进一步验证对于在管理BE的临床实施至关重要.

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