长期接触纳米颗粒会改变人类单细胞衍生的巨细胞中与衰老相关的标记物和免疫反应
Henry Lee1, Moritz Häffner1, Sandor Balog1,2
1Adolphe Merkle Institute, University of Fribourg, Switzerland, Chemin des Verdiers 4, Fribourg, Switzerland. barbara.rothen@unifr.ch.
Nanoscale
|February 12, 2026
概括
这项研究表明,长时间接触纳米粒子 (NP) 会以特定物质的方式影响巨细胞衰老标志物和免疫功能. 黄金NP增加炎症,二氧化NP具有较低的炎症潜力,而PETNP影响细胞循环调节.
科学领域:
- 免疫学 免疫学 免疫学
- 纳米技术纳米技术
- 细胞生物学 细胞生物学
背景情况:
- 巨细胞对于组织平衡至关重要,但可以经历衰老,损害免疫功能.
- 工程和环境纳米颗粒 (NP) 对巨细胞衰老和免疫的影响,特别是长期暴露后,尚不清楚.
研究的目的:
- 调查长时间接触黄金 (AuNPs),二氧化 (SiO2 NPs) 和聚乙烯二甲 (PET NPs) 对巨细胞衰老标志物和免疫功能的影响.
- 描述人类单细胞衍生巨细胞 (MDMs) 中老化相关特征的特定物质影响.
主要方法:
- 人类MDM在体外培养长达10天,以诱导衰老.
- 许多MDM暴露在AuNP,SiO2NP和PETNP中.
- 分析了衰老标志物 (SA-β-gal,p16,IL-6,IL-8) 和免疫能力,以评估NP的影响.
主要成果:
- 长时间的NP暴露以物质依赖的方式调节衰老标志物和免疫功能.
- AuNPs诱导了显著的炎症反应.
- SiO2 NPs表现出较低的炎症潜力,而PET NPs调节了与细胞周期调节相关的CDKN2A基因表达.
结论:
- 长期的NP行为和对巨细胞衰老和免疫功能的物质特异性影响需要仔细的表征.
- 这项研究通过检查非增殖性巨细胞中调制老化特征,提供了对慢性NP积累的功能后果的见解.
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