相关实验视频
Updated: Feb 13, 2026

10:01
Microfluidic Model to Mimic Initial Event of Neovascularization
Published on: April 10, 2021
5.2K
什么预测了随后的骨相关事件,以及与死亡率相关的因素在初始事件和后续事件后如何不同?
Hung-Ho Yen1, Paul T Ogink2, Hung-Kuan Yen1
1Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Clinical orthopaedics and related research
|February 12, 2026
概括
高龄,男性性别,侵略性瘤,高性酸酶和大脑转移会增加转移性骨疾病患者随后发生骨相关事件的风险. 建议通过加强监测进行早期检测.
科学领域:
- 在瘤学瘤学.
- 整形外科 整形外科 整形外科
- 放射学 放射学是一门学科.
背景情况:
- 转移性骨病由于衰弱症状和预后不佳而带来了重大挑战.
- 改进的治疗方法导致更长的存活时间,增加了长期骨相关事件的风险.
- 初始骨相关事件的预后因素可能不适用于随后的事件.
研究的目的:
- 确定与随后骨相关事件的更高风险相关的因素,将死亡视为竞争风险.
- 比较与最初和随后的骨相关事件患者之间的死亡率相关的因素.
主要方法:
- 在2010年至2018年期间,对3814名成年患者进行了骨转移治疗的回顾性研究.
- 利用一个全面的机构医疗数据库进行纵向数据整合.
- 应用竞争风险和Cox比例危险模型来分析因素.
主要成果:
- 随后的骨相关事件的独立风险因素包括年龄,男性性别,侵略性瘤类型,性酸酶升高和大脑转移.
- 83%的与死亡相关的因素在最初和随后的事件组中都显示出类似的关联.
- 诸如国际正常化比率升高等因素在随后的事件组中与死亡率有较强的关联.
结论:
- 高龄,男性性别,侵略性瘤,性酸酶升高和大脑转移与随后骨相关事件的风险增加有关.
- 建议加强对高危患者的监测和早期检测策略.
- 结果可以为更好的临床管理提供预测模型的开发提供信息.
相关概念视频
Integration of Synaptic Events
4.2K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
4.2K
Schwarzschild Radius and Event Horizon
2.8K
No object with a finite mass can travel faster than the speed of light in a vacuum. This fact has an interesting consequence in the domain of extremely high gravitational fields.
The minimum speed required to launch a projectile from the surface of an object to which it is gravitationally bound so that it eventually escapes the object’s gravitational field is called the escape velocity. The escape velocity is independent of the mass of the object. Merging the idea of escape...
The minimum speed required to launch a projectile from the surface of an object to which it is gravitationally bound so that it eventually escapes the object’s gravitational field is called the escape velocity. The escape velocity is independent of the mass of the object. Merging the idea of escape...
2.8K
Initiation of Translation
39.2K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.2K
Initiation of Translation
8.2K
8.2K
Predicting Molecular Geometry
46.1K
VSEPR Theory for Determination of Electron Pair Geometries
46.1K
Transcription Factors
82.9K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.9K

