对PPLA年龄的菌体:无沙门氏菌家禽料的有效方法
Elżbieta Fornal1, Anna Pękala1, Marcela Łaszkiewicz1
1Proteon Pharmaceuticals S.A., Łódź, Poland.
Microbiology spectrum
|February 12, 2026
概括
一种细菌菌尾酒BAFASAL有效降低了家禽料中的沙门氏菌污染. 通过后颗粒液体应用 (PPLA) 应用,它在实验室和活肉研究中显著降低了沙门氏菌水平,确保了料安全.
科学领域:
- 食品安全 食品安全
- 微生物学 微生物学
- 动物科学动物科学
背景情况:
- 沙门氏菌是主要的食源性病原体,家禽是人类感染的常见来源.
- 污染的家禽料是沙门氏菌向群体传播的主要途径.
- 抗微生物耐药性需要使用替代策略来控制食物链中的细菌病原体.
研究的目的:
- 评估菌体尾酒BAFASAL在预防和减少家禽料中沙门氏菌污染的有效性.
- 在体外和体外模型中评估通过颗粒后液体应用 (PPLA) 输送的BAFASAL的有效性.
- 探索BAFASAL作为抗生素的安全替代品,用于控制动物料中的沙门氏菌.
主要方法:
- 在人工污染的家禽料上进行了BAFASAL在两个度 (1×104和5×104PFU/g) 的体外试验.
- 在体内挑战性研究中,使用用BAFASAL/PPLA处理或未处理的沙门氏菌污染料养的肉.
- 监测不同时间点在作物样本和内含量中沙门氏菌的存在.
主要成果:
- 这两种BAFASAL度都减少了沙门氏菌spp. 在体外至少有三个日志.
- 在体内,3天后,从接受BAFASAL/PPLA处理料的鸟类的作物样本中没有检测到沙门氏菌.
- 在接受治疗的鸟类的内含量中,观察到沙门氏菌殖民的统计学显著减少超过四个日志.
结论:
- 通过PPLA应用的菌体尾酒BAFASAL在预防和减少家禽料中的沙门氏菌污染方面非常有效.
- 巴法萨尔代表了一种有前途,安全和可行的替代常规抗菌剂,以确保料安全.
- PPLA方法允许在工业家禽养殖中可扩展地应用菌体,以减轻食物链病原体风险.
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