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The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
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In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
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谱系协调细胞形状和信号,对于表皮分化至关重要.

Arad Soffer1, Aishwarya Bhosale2,3, Roohallah Ghodrat2,3

  • 1Gray School of Medical Sciences, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

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概括

谱系组织了actomyosin皮质,将细胞形状和表皮中的分化联系起来. 这种细胞骨调节对于表皮屏障形成和组织发育至关重要.

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科学领域:

  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.
  • 发展生物学 发展生物学

背景情况:

  • 细胞形状和命运是相互关联的,但皮质细胞骨架整合这些过程的机制尚未完全理解.
  • 多层表皮作为研究细胞形状如何影响分化和组织组织的模型.

研究的目的:

  • 研究光谱在组织actomyosin皮质和整合细胞形状与信号通路中的作用.
  • 阐明皮层细胞骨组织如何指导细胞形状转变和表皮中的细胞命运决定.

主要方法:

  • 使用小鼠表皮作为模型系统.
  • 采用了高分辨率成像和激光切除技术.
  • 研究了αII-谱素 (Sptan1) 在表皮分化和屏障形成中的功能.

主要成果:

  • 失去了αII光谱破坏了表皮细胞的形状,损害了分化,并损害了屏障功能.
  • E-cadherin组织层特异性皮质动因和光谱网络,影响细胞形状和命运.
  • 这些网络消除了张力,并保留了EGFR和TRPV3等信号分子,以促进终端分化.

结论:

  • 谱素对于组织actomyosin皮质至关重要,将细胞形状与表皮分化的信号整合起来.
  • 极化皮质细胞骨组织指导细胞形状和命运过渡,对于建立表皮屏障至关重要.