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发酵红人参恢复与年龄相关的胰岛素平衡和小鼠肠道微生物组平衡
Da-Yeon Lee1, Jing Liu2, Gopal Lamichhane1
1Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Biology
|February 12, 2026
概括
发酵红人参 (FRG) 补充剂在老年小鼠中改善了与年龄相关的胰岛素抵抗和肠道功能障碍. FRG增强胰岛素信号传递,促进有益的肠道细菌,表明其作为抗衰老食补充剂的潜力.
科学领域:
- 老年学是指老年学的学科.
- 代谢健康 代谢健康
- 微生物组研究 微生物组研究
背景情况:
- 生物衰老会损害肝肠沟通,导致胰岛素抵抗,2型糖尿病和肠道功能失调.
- 发酵红色人参 (FRG),富含人参化物,具有抗炎和抗糖尿病的特性.
- FRG对生物衰老和与年龄相关的代谢功能障碍的影响在很大程度上仍未被探索.
研究的目的:
- 调查FRG在改善老年男性小鼠因年龄而导致的胰岛素平衡障碍和肠道失调症的健康益处.
- 评估FRG对参与胰岛素信号和炎症的关键分子通路的影响.
- 分析FRG对老年小鼠肠道微生物群组成的影响.
主要方法:
- 年龄较大的雄性小鼠 (19个月大) 接受了正常食 (NCD) 或NCD补充FRG (300毫克/公斤) 14周的食.
- 通过测量40kDa (PRAS40) 激活的肝蛋白激酶B (AKT) 和富含proline的AKT基质来评估胰岛素稳定性.
- 肝炎通过mRNA表达的炎症性细胞因子和组织学分析来评估.
- 用16S rRNA测序分析了肠道微生物组成,以确定细菌种群的变化.
主要成果:
- 通过激活肝脏AKT和PRAS40.0,FRG补充剂显著改善了胰岛素平衡.
- 施用FRG抑制了促炎性细胞因子的表达,并减少了肝脏中的炎症透物.
- FRG调节了肠道微生物群,降低了Firmicutes/Bacteroidetes的比率,并丰富了像Muribaculaceae和Parasutterella这样的有益品种.
- FRG减少了有害属的丰富性,包括Erysipelotrichaceae和Dubosiella.
结论:
- 发酵红人参在对抗年龄驱动的代谢功能障碍方面具有显著的健康益处.
- 在老年小鼠中,FRG改善了胰岛素平衡,并减少了肝炎.
- FRG积极调节肠道微生物群的组成,表明其作为一种抗衰老的食补充剂的潜力,用于管理与年龄相关的代谢失调.
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