在接受童年疫苗接种疫苗的老年人中对MPXV具有强大的适应性免疫力
Chris Davis1, Jianmin Zuo2, Rachel Bruton2
1MRC University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK.
Biology
|February 12, 2026
概括
儿童天花疫苗接种提供了对麻病毒 (MPXV) 的长期免疫力. 这种在79岁以上的成年人中评估的免疫力显示出持久的抗体和T细胞反应持续超过70年.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 猿病毒 (MPXV) 引起mpox,与增加的人与人之间的传播.
- 麻疹疫苗 (vaccinia) 提供对MPXV的交叉保护,但其长期耐用性尚不清楚.
研究的目的:
- 评估长期的幽默和细胞免疫反应对MPXV在儿童中接种了小天花疫苗的个人.
- 确定儿童疫苗接种是否能提供对MPXV.病毒的持久免疫力.
主要方法:
- 招募了23名报告儿童疫苗接种的成年人 (79-94岁) (1925-1940年).
- 通过ELISA和中和试验评估MPXV特异性IgG抗体.
- 使用IFN-γ ELISpot试验评估细胞免疫力.
主要成果:
- 所有历史上接种疫苗的参与者都显示出MPXV反应性IgG,其水平与最近接种疫苗的个人相当.
- 在所有参与者中检测到对MPXV的功能中和活性 (78%显示≥50%中和).
- 在所有已接种疫苗的捐赠者中都存在可检测的T细胞反应,尽管在90岁以上的捐赠者中减少了.
结论:
- 儿童疫苗接种引发了针对MPXV的持久性幽默和细胞免疫力,这种免疫力持续了70多年.
- 过去的天花疫苗接种情况可能是对Mpox的保护的一个重要因素.
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