黄素对急性淋巴细胞白血病的抗白血病特性:系统性审查
Teck Chee Soh1, Ying Hui Tan1,2, Pen Han Heng1
1Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Malaysia.
Biology
|February 12, 2026
概括
黄素通过抑制增殖和诱导亡,对急性淋巴细胞白血病 (ALL) 产生多重向的抗白血病作用. 临床使用受到生物利用度差的限制,需要进一步的研究和临床试验.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 自然产品
背景情况:
- 急性淋巴细胞白血病 (ALL) 是一种具有具有挑战性的耐治疗性和副作用的血液癌症.
- 从黄中提取的黄,在各种癌症中表现出抗癌性质,包括白血病.
- 本综述综合了黄素在ALL中的抗白血病作用和机制的证据.
研究的目的:
- 系统地审查临床前和临床研究关于黄素在ALL中的疗效.
- 阐明黄素抗白血病活性背后的分子机制.
- 确定黄素在ALL中的临床应用的障碍和未来方向.
主要方法:
- 在2025年8月,在主要数据库 (PubMed,Scopus,Ovid MEDLINE,Web of Science) 进行了全面的文献搜索.
- 研究包括体外,体内和人体研究,研究黄素对ALL的影响.
- 从2034个记录中,根据预定义的包含和排除标准,选择了26篇文章.
主要成果:
- 库尔库抑制了ALL细胞增殖,通过各种途径诱导细胞毒性和亡,包括ROS生成,DNA损伤和酶激活.
- 抑制了JAK/STAT和PI3K/AKT等关键信号通路,同时抑制了BCR-ABL,WT1和MDR1.
- 实体研究中的证据有限,没有确定人体临床试验.
结论:
- 黄素通过多个分子点在ALL中表现出广泛的抗白血病活性.
- 生物可用性差和临床数据有限阻碍了直接临床转化.
- 未来的研究应该优先提高黄素的生物可用性,并进行强大的临床试验.
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