线粒体哈普集团和左心室扩张功能障碍在艾滋病毒感染者和没有艾滋病毒感染者中
Craig Cronin1, Jing Sun2, Jorge R Kizer3,4
1Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
The Journal of infectious diseases
|February 12, 2026
概括
线粒体DNA变异和二氧化核糖类相似药物使用与艾滋病毒感染男性的腹功能障碍有关. 这些发现表明HIV相关心脏病监测和治疗的潜在目标.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 传染性疾病 传染性疾病
背景情况:
- 心脏功能障碍在艾滋病毒感染者 (PWH) 中比没有艾滋病毒感染者 (PWoH) 中更为普遍.
- 线粒体功能障碍是与艾滋病毒相关的心脏病发病的一个可疑因素.
- 这项研究探讨了 mitochondrial DNA (mtDNA) 变异,特定抗逆转录病毒药物和 PWH.中左心室扩张功能障碍 (LVDD) 之间的联系.
研究的目的:
- 调查mtDNA单基组,dideoxynucleoside模拟物 (D-药物) 的使用,以及艾滋病毒感染者和未感染者的LVDD之间的关联.
- 确定艾滋病毒状态是否会改变mtDNA变异和LVDD之间的关系.
主要方法:
- 利用了来自多中心艾滋病队列研究和妇女机构间艾滋病毒研究的回声心电图数据.
- 在抗逆转录病毒疗法标准上使用心脏功能的特征定义LVDD.
- 推断mtDNA单基组并进行后勤回归来评估与LVDD,D药物的关联,以及它们在艾滋病毒感染者和未感染者的男性和女性之间的相互作用.
主要成果:
- 在女性中,LVDD的患病率为29%,在男性中为24%.
- 在艾滋病毒感染的男性中,欧洲哈普洛组H显示LVDD几率降低,而JT增加了几率. D-药物暴露与较高的LVDD概率相关.
- 在女性中没有发现显著的单元组关联;然而,HIV血清状况改变了与LVDD的L2和L3单元组关联.
结论:
- 线粒体遗传变异和D-药物使用与艾滋病毒感染男性的LVDD风险变化有关.
- 这些因素可能是针对PWH进行有针对性的监测或治疗干预的关键生物机制.
- 需要进一步的研究来探索这些关联,特别是性别特异性差异和相互作用.
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