循环T细胞和瘤微环境配置文件与免疫检查点阻塞结果在肉瘤中的关联
Evan Rosenbaum1, Fiona Ehrich1, Mohammad Yosofvand1
1Memorial Sloan Kettering Cancer Center New York, NY United States.
概括
识别循环T细胞免疫型和瘤微环境亚型可以预测肉瘤中的免疫检查点阻塞 (ICB) 反应. 增殖性T细胞免疫型表明结果不佳,而免疫丰富/非纤维性瘤微环境表明对ICB治疗的反应优越.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 免疫检查点阻塞 (ICB) 在肉瘤中的有效性仅限于一小部分患者.
- 预测生物标志物对于优化患者选择ICB治疗至关重要.
研究的目的:
- 确定与瘤患者对ICB的反应和耐药性相关的生物标志物.
- 探索循环T细胞免疫型和瘤微环境 (TME) 亚型作为ICB结果的预测因素.
主要方法:
- 在ICB临床试验中分析了来自肉瘤患者的外周血液单核细胞 (PBMC) 和瘤组织.
- 利用流细胞测量来定义T细胞免疫型和RNA测序来分类TME亚型.
- 将深度学习模型应用于血素和素 (H&E) 幻灯片,用于淋巴细胞聚合物的量化.
主要成果:
- 一种增殖性 (PRO) 循环T细胞免疫型与较低的整体存活率 (OS) 相关联.
- 免疫丰富/非纤维性TME亚型与更高的反应率,更好的无进展生存率和更长的OS有关.
- 自动化H&E幻灯片分析显示了识别免疫丰富的TME特征的潜力.
结论:
- PRO T 细胞免疫型预测ICB结果不佳,而免疫丰富/非纤维性TME预测肉瘤的良好结果.
- 多模式生物标记方法,包括T细胞免疫型和TME特征,对于预测ICB反应至关重要.
- 对H&E幻灯片的自动化分析为TME评估在免疫治疗选择中提供了一个有前途的工具.
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