甲状腺/甲状腺功能和化物:线粒体DNA和SOD遗传变异的作用
Qing Sun1, Zichen Feng1, Long Sun2
1Department of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Journal of endocrinological investigation
|February 12, 2026
概括
儿童过度化物暴露与甲状腺变化和副甲状腺激素减少有关,线粒体DNA拷贝数在女孩中起着调解作用. 在SOD2和SOD3中的遗传变异可能会影响这些化物诱导的甲状腺效应.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 新出现的证据表明过度化物暴露可能会损害甲状腺和副甲状腺功能,涉及氧化应激和线粒体功能障碍.
- 然而,关于化物对甲状腺/副甲状腺健康的影响及其与与氧化应激相关的单核酸多态 (SNP) 相互作用的流行病学数据有限.
研究的目的:
- 调查尿液化物 (UF) 水平与儿童甲状腺/副甲状腺功能之间的关联.
- 为了检查线粒体DNA拷贝数 (mtDNA-CN) 和UF和超氧化物脱酶 (SOD) SNPs之间的基因环境相互作用的调解效应.
主要方法:
- 在中国东县化物暴露地区对401名儿童 (7-13岁) 进行的横截面研究.
- 分析尿液中的化物含量,甲状腺体积 (Tvol),副甲状腺激素 (PTH) 和mtDNA-CN.
- 使用通用多因素维度减小 (GMDR) 调查了UF和SOD2/SOD3基因多态性之间的相互作用.
主要成果:
- 在儿童中,增加的UF水平与更大的Tvol,降低的PTH和减少的mtDNA-CN有关.
- 在女孩中,相对mtDNA-CN部分调解了UF和Tvol之间的关联 (33.08%的调解).
- 特定的SOD2 (rs4880) 和SOD3 (rs13306703) 基因型与UF相互作用,影响Tvol和PTH水平.
结论:
- 饮用水中的化物暴露与儿童甲状腺功能改变有关.
- 线粒体功能障碍,由减少的mtDNA-CN表示,部分调解化物对女孩甲状腺体体积的影响.
- SOD2和SOD3的遗传变异可能会改变儿童对化物诱导的甲状腺功能障碍的易感性.
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