对动脉旋转标记序列的调整,用于在0.35 T MR-Linac上评估大脑输液
Philipp Wallimann1, Philip Wild2, Petros Martirosian3
1Department of Radiation Oncology, University Hospital Zurich and University of Zurich, Rämistrasse 100, 8091, Zurich, CH, Switzerland. philipp.wallimann@usz.ch.
研究人员为0.35特斯拉MR-Linac机器开发了一种10分钟的动脉旋转标记 (ASL) 协议,实现可重复的脑血流 (CBF) 测量,以改善放射治疗. 这种方法在治疗期间有望提高目标划分和响应评估.
科学领域:
- 放射治疗和医学成像技术
- 神经成像和输液评估
背景情况:
- 混合MR-Linac设备将MRI与放射治疗的线性加速器集成在一起.
- 在治疗期间的功能性MRI可以增强目标划分并评估治疗反应.
- 动脉旋转标记 (ASL) 提供非对比性输液成像.
研究的目的:
- 为了研究在0.35特斯拉 (T) MR-Linac.上获取ASL perfusion图像的可行性.
- 为了为0.35 T MR-Linac环境优化ASL序列参数.
- 使用优化协议评估脑血流 (CBF) 测量的可重复性.
主要方法:
- 开发了一种信号模型,用于流量敏感的交替反转恢复 (FAIR) 平衡稳定状态自由前行 (bSSFP) ASL序列.
- 优化了0.35 T MR-Linac的序列参数,并检查了健康志愿者的大脑中的信号依赖性.
- 在6名健康志愿者中,将调整后的MR-Linac协议中的CBF测量的重复性与临床3T扫描仪进行了比较.
主要成果:
- 开发的信号模型准确地描述了ASL测量,反转时间依赖的偏差很小.
- 灰色和白质的脑血流 (CBF) 值在0.35 T MR-Linac上与3 T扫描仪相比系统地更高.
- 对于CBF测量的可重复系数在两台扫描仪中都是相似的,大约为16-17%.
结论:
- 在0.35 T MR-Linac.上,一个调整的10分钟FAIR bSSFP ASL协议是可行的.
- 这种协议可以进行可重复的脑血流 (CBF) 测量.
- 这些发现支持ASL在MR-Linacs上的辐射疗法应用的潜力.
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