介素-1受体辅助蛋白表达可能与胰岛-默认模式网络连接和纤维肌痛中的临床抑郁有关:一项初步探索性研究
Nguyen Thanh Nhu1, San-Yuan Wang2, Chia-Li Han2
1International PhD Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; and Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
介素-1受体辅助蛋白 (IL-1RAP) 的表达影响纤维肌痛患者的大脑连接,可能调节抑郁症症状. 这表明IL-1RAP可能在纤维肌痛中出现的各种抑郁体验中发挥作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 纤维肌痛 (FM) 呈现出异质的临床抑郁症.
- 介素-1受体辅助蛋白 (IL-1RAP) 和前胰岛 (AI) -默认模式网络 (DMN) 的连接性可能解释了这种异质性.
研究的目的:
- 为了研究IL-1RAP表达,AI-DMN连接和FM患者的临床抑郁症之间的关联.
主要方法:
- 17名FM患者接受了临床评估,血清蛋白质组分析IL-1RAP,并在基线和1年随访时进行脑MRI.
- 功能性MRI (fMRI) 用于分析双边AI和DMN区域之间的基于种子的功能连接 (FC).
- 坚固和回归检查了IL-1RAP,AI-DMN FC和贝克抑郁指数版本II (BDI-II) 分数之间的关系.
主要成果:
- IL-1RAP表达显著预测了双边AI和后带皮层 (PCC) 之间的FC.
- 右AI-PCC FC对BDI-II分数产生了负面影响.
- IL-1RAP和右AI-PCC FC之间的相互作用在基线显著影响了抑郁症得分,但在随访时没有.
结论:
- 通过AI和PCC连接,IL-1RAP可以调节FM患者的抑郁症.
- 结果表明IL-1RAP在FM抑郁症的症状异质性中的作用.
- 需要进一步的大规模研究来证实这些初步发现.
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