亚洲和原住民夏威夷和其他太平洋岛屿群体的PREVENT方程表现
Michael Au1, Yiyi Zhang2, Matt M Zhou3
1Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California.
JAMA network open
|February 12, 2026
概括
在PREVENT方程中,在不同族群中显示出强有力的心血管风险预测. 然而,准确性各不相同,突出需要考虑特定的亚洲和原住民夏威夷人/其他太平洋岛民的人口差异.
科学领域:
- 心血管疾病风险预测预测
- 在健康方面存在差异.
- 流行病学 流行病学
背景情况:
- 预防方程 (预测心血管疾病事件风险) 于2023年开发,以估计10年心血管疾病 (CVD) 风险.
- 这些方程在特定的亚洲和原住民夏威夷和其他太平洋岛民族群中的准确性以前是未知的.
研究的目的:
- 评估PREVENT基础和完整方程的预测精度.
- 评估非西班牙裔白人,亚洲人和夏威夷原住民和其他太平洋岛民人口的表现,包括分类的亚洲族群.
主要方法:
- 对542,848名30-79岁没有心血管疾病的成年人进行了回顾性队列研究.
- 利用凯泽永久南加利福尼亚州2009-2019年的会员数据.
- 通过哈雷尔C指数和平均校准,将预测的10年心血管疾病风险 (使用PREVENT基础和完整方程) 与观察到的事件进行了比较.
主要成果:
- 在PREVENT基础方程中,所有主要的种族/民族群体都表现出良好的歧视 (C指数为0.757-0.773).
- 在亚洲族群中,表现不同 (C指数为0.738-0.806).
- 方程式通常高估了非西班牙裔亚洲人的风险,低估了非西班牙裔夏威夷原住民/其他太平洋岛民和非西班牙裔白人风险.
结论:
- PREVENT方程式顯示了整體強大的心血管風險預測能力.
- 在不同的亚洲和原住民夏威夷人/其他太平洋岛民族群中,表现存在显著的异质性.
- 认识到这种种族差异对于在不同人群中准确评估心血管疾病风险至关重要.
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