嫌疑人名单指导高通量查 (SLIG-HTS) 识别了与先进胚胎发育时间相关的环境物质
Peng Wang1, Yu Li2, Ziyu Zhang1
1State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Environmental science & technology
|February 12, 2026
概括
环境污染物可以加速胚胎发育,带来风险. 这项研究确定了包括硫胺抗生素在内的物质,这些物质在低度下促进斑马鱼的发育时间,突出了潜在的生态问题.
科学领域:
- 环境毒理学环境毒理学
- 发育生物学是发展生物学.
- 生态毒理学 生态毒理学
背景情况:
- 环境污染物往往会延缓胚胎发育,但尽管存在风险,加速发育的研究较少.
- 了解影响发育时间的因素对于评估化学物质暴露对生态的影响至关重要.
研究的目的:
- 制定和应用查策略,以识别加速胚胎发育时间的环境物质.
- 研究已识别的化合物在环境相关度下对斑马鱼发育的影响.
主要方法:
- 开发了一个以嫌疑人名单为指导的高通量选策略.
- 综合文献知情的嫌疑人名单与分阶段解决的终点评估.
- 追溯选了超过9300个毒性记录,并在斑马鱼中实验验验证了46个可疑化合物.
主要成果:
- 确定了27种 (58.7%) 影响斑马鱼胚胎形态终点的化合物.
- 硫胺抗生素sulfadiazine和sulfamethoxazole在ng/L到低μg/L度时显示出显著的影响.
- 转录组分析揭示了神经肌肉和心血管发育的途径水平的变化,表明发育时间的改变.
结论:
- 综合方法成功地确定了环境物质,特别是硫胺,这些物质在适当的度下促进胚胎发育时间.
- 这些发现突显了硫胺类的潜在全类影响及其生态相关性.
- 由于环境污染物的先进胚胎发育是一个重要的生态毒理学问题.
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