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Updated: Feb 14, 2026

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PPARα-NFκB异构体通过自身IL-6的分泌产生来调解肥胖诱导的透缩功能障碍

Shin-Ichi Oka1, Eun-Ah Sung1, Peiyong Zhai1

  • 1Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, United States of America.

The Journal of clinical investigation
|February 12, 2026
PubMed
概括

肥胖引起的高自由脂肪酸 (FFAs) 直接增加IL-6在心脏细胞,导致腹功能障碍. 这一途径涉及PPARα和NFκB,突出显示IL-6是肥胖心肌病的关键因素.

关键词:
心脏病学 心脏病学代谢过程中的代谢.转录 转录 转录 转录

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