在癌症治疗中针对PI3K/Akt/mTOR介导的自途径的天然产品:最近的进展和临床前景
Jingwen Hu1,2, Yulin Guo2, Liang Ren3,4
1The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Journal of natural products
|February 12, 2026
概括
自然产品可以准PI3K/Akt/mTOR通路和自来对抗癌症. 本综述探讨了这些天然化合物如何抑制瘤生长并提高治疗疗效,尽管面临着药理动力学挑战.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- PI3K/Akt/mTOR通路和自是癌细胞增殖,生存和耐药性的关键调节者.
- 这种途径的失调是癌症进展和治疗失败的重要驱动因素.
研究的目的:
- 审查针对癌症PI3K/Akt/mTOR介导的自途径的天然产品最近 (2015-2025) 的进展.
- 阐明各种自然产品类对这种途径的作用机制及其对癌症模型的影响.
- 分析天然产品在癌症治疗的组合疗法中的潜力.
主要方法:
- 对2015年至2025年间发表的研究的文献综述.
- 对调节PI3K/Akt/mTOR通路和自的自然产品 (类,黄类,类,多类) 的研究进行综合和评估.
- 对涉及自然产品,化疗,向药物和免疫治疗的组合疗法的临床前数据的分析.
主要成果:
- 在各种癌症模型中,各种天然产品类有效调节PI3K/Akt/mTOR通路和自流,抑制增殖和促进亡.
- 天然产品在组合疗法中表现有前途,提高疗效,降低毒性,克服耐药性.
- 显著的翻译挑战,特别是药理动力学不佳,阻碍了这些化合物的临床应用.
结论:
- 天然产品是针对癌症PI3K/Akt/mTOR-自轴的一个有希望的治疗策略.
- 需要进一步的研究来克服药理动力学限制,并将这些化合物推向临床转化.
- 整合机理性见解,组合策略和临床数据对于开发有效的基于天然产品的癌症治疗非常重要.
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