延迟到长期的注射抗精神病药物启动和精神病医院住院治疗在第一次精神分裂症
Sung Woo Joo1, Jungsun Lee1,2
1Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
The Journal of clinical psychiatry
|February 12, 2026
概括
在精神分裂症早期开始使用长效注射抗精神病药物 (LAI),可以改善患者的坚持,但增加住院治疗. 早期的LAI启动减少了精神病医院住院的负担,支持当前的治疗指南.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 长效注射抗精神病药物 (LAI) 建议用于早期精神分裂症.
- 启动LAI治疗的最佳时间仍在调查中.
研究的目的:
- 检查LAI启动时间对第一发精神分裂症患者的治疗中止和住院时间的影响.
- 为早期精神分裂症管理提供临床指导方针.
主要方法:
- 来自韩国医疗保险审查和评估服务索赔数据库的6380名第一发精神分裂症患者的分析.
- 对LAI启动间隔的分类 (诊断后0-1,1-2,2-3,3-4,4-5,>5年).
- 使用考克斯和线性回归模型进行统计分析,以评估停药和住院日数.
主要成果:
- 延迟LAI启动 (>2年后的诊断) 与较低的治疗中止率有关.
- 较晚的LAI启动与更大的精神病医院住院负担相关,特别是在以前住院的患者中.
- 在>5年延迟组中,较长的延迟显著增加了住院日数.
结论:
- 虽然延迟LAI的启动可能会改善坚持,但早期启动对于减少精神分裂症的整体精神病医院住院负担至关重要.
- 这些发现支持推早期治疗精神分裂症的LAI的指导方针.
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