在年轻和年长的成年人中,在右手和左手灵巧测试期间,前额叶皮层连接性
Manjiri Kulkarni1,2,3, Peter Rassam2, Pedram Mouseli4,5
1Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada.
PloS one
|February 12, 2026
概括
老年人表现出改变前额叶皮层 (PFC) 功能连接在手的灵巧任务,特别是与非主导的手. 观察到神经活动配对增加,但没有提高任务效率.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 人类运动控制人体运动控制
背景情况:
- 衰老会影响前额叶皮层 (PFC) 在复杂的运动任务中激活和连接.
- 年轻和年长的成年人之间,手的灵巧表现和相关的神经活动有所不同.
研究的目的:
- 在右手和左手9孔杆测试 (R9HPT和L9HPT) 中比较PFC区域内的功能连接.
- 为了研究手工灵巧任务中PFC功能连接的年龄相关差异.
主要方法:
- 功能近红外谱学 (fNIRS) 在八个PFC区域测量了神经活动 (含氧血红蛋白).
- 时间序列分析评估了PFC区域之间的功能连接在时间R9HPT和L9HPT的年轻人和老年人.
主要成果:
- 与年轻人相比,老年人对R9HPT和L9HPT的完成时间较长.
- 在PFC区域内和PFC区域之间的功能连接模式在年龄组和人群之间有所不同.
- 增加的神经活动 (∆O2Hb) 与老年人较长的任务时间相关,特别是涉及特定的PFC区域.
结论:
- 年轻人和老年人之间,PFC的功能连接在手工敏捷性任务中不同.
- 非主导手和老年人需要更大的PFC连接,但这并不能提高任务效率.
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