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Updated: Feb 14, 2026

De Novo Generation of Somatic Stem Cells by YAP/TAZ
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Published on: May 7, 2018

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PI3K调节TAZ/YAP和mTORC1轴,可以协同准这些轴

Keith C Garcia1, Ali A Khan1, Krishnendu Ghosh1

  • 1Department of Pathology, The University of Iowa, Iowa City, United States of America.

JCI insight
|February 12, 2026
PubMed
概括

氨基酸3-酶 (PI3K) 信号驱动器通过TAZ/YAP驱动肉瘤的生长. 针对PI3K,TAZ/YAP-TEAD和mTORC1进行组合治疗,在临床前的肉瘤模型中显示出协同效应.

关键词:
癌症 癌症 癌症 癌症细胞生物学 细胞生物学在瘤学瘤学.信号传导传导是指信号的传导.

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