Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Sign Test for Matched Pairs01:17

Sign Test for Matched Pairs

428
The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
To conduct the sign test, we first calculate the differences in...
428
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

430
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
430
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
Clinical Trials01:16

Clinical Trials

10.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.9K
Wilcoxon Signed-Ranks Test for Matched Pairs01:09

Wilcoxon Signed-Ranks Test for Matched Pairs

507
The Wilcoxon signed-rank test for matched pairs evaluates the null hypothesis by combining the ranks of differences with their signs. It essentially tests whether the median of the differences in a population of matched pairs is zero. Since the test incorporates more information than the sign test, it generally yields more trustable conclusions. This test also does not require the data to follow a normal distribution, but two conditions must be met for it to be applicable: (1) the data must...
507
Subviral Agents01:29

Subviral Agents

589
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
589

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The effect of Traditional Chinese Medicine Tuina massage combined with family-based prevention on visual acuity in children and adolescents with myopia: A case report of single-group interventional study.

Medicine·2026
Same author

Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov.

Frontiers in pediatrics·2025
Same author

Effect of Danlu capsules for the treatment of breast hyperplasia with mastalgia: a multicenter, double-blind, randomized controlled trial protocol.

Frontiers in medicine·2025
Same author

Optimization of Clinical Trial Design and Decision-Making for Heart Failure with Preserved Ejection Fraction (HFpEF): A Meta-Analysis Based on a Placebo Response Model.

Cardiovascular therapeutics·2025
Same author

Evolution of Clinical Trials of Systemic Therapies for Hepatocellular Carcinoma Between 2005 and 2024: Based on ClinicalTrials.gov.

Gastro hep advances·2025
Same author

Treatment of acute intracerebral haemorrhage with a Chinese herbal formula (Shengdi Dahuang Decoction): a multicentre, double-blind, randomised, placebo-controlled trial.

Stroke and vascular neurology·2025

相关实验视频

Updated: Feb 14, 2026

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.3K

EC2Seq2Sql:患者试验与LLM代理商的匹配

Liu Yang1, Yongzhong Han1, Liang Liu2

  • 1School of Electronic and Electrical Engineering, Shanghai University of Engineering Science, Shanghai, China.

PloS one
|February 12, 2026
PubMed
概括

EC2Seq2Sql自动将临床试验资格标准转换为电子健康记录 (EHR) 数据的SQL查询. 该框架通过将自然语言标准和结构化EHR方案相结合,增强临床试验的患者查能力.

更多相关视频

Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides
05:16

Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides

Published on: May 7, 2020

7.3K
Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research
04:49

Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research

Published on: May 5, 2021

7.1K

相关实验视频

Last Updated: Feb 14, 2026

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.3K
Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides
05:16

Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides

Published on: May 7, 2020

7.3K
Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research
04:49

Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research

Published on: May 5, 2021

7.1K

科学领域:

  • 生物医学信息学 生物医学信息学
  • 医疗保健中的人工智能
  • 临床试验招聘 临床试验招聘

背景情况:

  • 临床试验招聘面临挑战,原因是自然语言资格标准和结构化电子健康记录 (EHR) 数据之间的差异.
  • 手动的患者查试验资格是耗时的,容易出现错误.

研究的目的:

  • 开发和评估EC2Seq2Sql,这是一个自动化框架,用于将叙述性的临床试验资格标准转换为可执行的SQL查询.
  • 提高使用EHR数据进行临床试验的患者识别的效率和准确性.

主要方法:

  • 一个两阶段的框架: 1) 基于BART的语义解析器将文本标准转换为结构化模式. 2) 基于LLM的代理接地模式与数据库模式并生成SQL查询.
  • 对ClinicalTrials.gov数据集和现实世界肝细胞癌EHR队列的评估.

主要成果:

  • 巴特分析器实现了0.8067的ROUGE_L和0.8427.7的BLEU.
  • SQL生成阶段达到0.84的准确匹配精度和0.91的执行精度.
  • 对现实世界队列的查询实现了0.88的临床匹配准确度,证明了有效的患者检索.

结论:

  • EC2Seq2Sql有效地将符合条件的转换自动化为基于EHR的患者查的SQL.
  • 该框架减少了手动查的努力,并提供了一种可复制的队列识别方法.
  • 对于大规模的多中心部署,需要进一步验证.