数字双胞胎在生育,辅助生殖技术和怀孕:一个系统的审查
Alexandre Vallée1, Gaby Moawad2, Anis Feki3
1Department of Epidemiology and Public Health, Foch Hospital, Suresnes, France.
Reproductive biomedicine online
|February 12, 2026
概括
数字双胞胎为生育,辅助生殖技术 (ART) 和怀孕提供了个性化的模拟. 虽然有前途,但它们在生殖医学中的临床应用目前是有限的和理论的,需要进一步开发.
科学领域:
- 生殖医学 生殖医学
- 计算生物学 计算生物学
- 医疗模拟 医疗模拟
背景情况:
- 数字双胞胎,即生物系统的虚拟表示,在生殖医学中越来越受欢迎.
- 它们为个性化模拟提供了机会,以增强生育治疗和怀孕结果.
- 目前的应用程序是分散的,并且在各种用途之间受到限制.
研究的目的:
- 系统地审查关于生育能力,辅助生殖技术 (ART) 和怀孕的数字双胞胎的证据.
- 确定数字双胞胎在生殖护理中的当前应用,结果,挑战和未来前景.
- 评估数字双胞胎技术在该领域临床实施的准备程度.
主要方法:
- 在PubMed,EMBASE,Scopus和IEEE Xplore中进行了系统的文献搜索,直到2025年7月.
- 包括的研究将数字双胞胎应用于人类或in-silico生育,ART或怀孕模型.
- 分析了八项原始研究和九项机理/概念性工作.
主要成果:
- 应用包括胚胎选择,试管婴儿建模,胎盘生理学,妊娠药理动力学和产妇内监测.
- 大多数研究都是预测性/描述性,静态性/批量合性,并且处于早期验证阶段.
- 偏差风险中等至高;只有两项研究严格符合数字双胞胎标准.
结论:
- 数字双胞胎显示出个性化生殖健康护理的巨大潜力.
- 然而,它们在生殖医学中的临床实用性目前主要是理论上的.
- 在建模准确度,数据整合和伦理考虑方面的进步对于未来的临床采用至关重要.
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