使用LINAC4和核子加速器使用质子和碳离子束FLASH放射生物学的可行性
Ivan Mihailov Tsanev1, Vladimira Markova2, Borislav Pavlov3
1Atomic Physic, Sofia University St Kliment Ohridski, 5 James Bourchier Blvd., Sofia, Bulgaria, Sofia, 1164, Bulgaria.
Physics in medicine and biology
|February 12, 2026
概括
研究加速器LINAC4和Nuclotron适用于超高剂量率 (UHDR) 和FLASH放射生物学. 它们的脉冲质子和碳离子束使FLASH效应能够进行精确的体外研究,从而推进机理学理解.
科学领域:
- 医学物理 医学物理
- 放射生物学的放射生物学
- 加速器物理学的物理学
背景情况:
- 超高剂量速率 (UHDR) 和FLASH辐射在放射生物学中显示出前景.
- 对于这些先进的辐射条件,使用研究加速器的可行性尚未得到充分研究.
- 精确的剂量传递和光束特征对于研究FLASH效应至关重要.
研究的目的:
- 评估用于UHDR和FLASH放射生物学的LINAC4 (CERN) 和Nuclotron (JINR) 加速器.
- 评估质子和碳离子束对于这些实验的适用性.
- 确定这些设施是否符合体外FLASH研究的物理要求.
主要方法:
- 使用GEANT4和FLUKA工具包进行蒙特卡洛模拟.
- 模拟光束传输,剂量沉积和空间剂量分布.
- 虚拟辐射设置与水幽灵和细胞培养容器模型.
主要成果:
- LINAC4 (160 MeV质子) 和Nuclotron (430 MeV/u碳离子) 提供了高空间精度.
- 在~5毫升的目标中达到均的剂量分布,包括布拉格峰值.
- 脉冲光束结构使UHDR传输用于精确控制的体外FLASH研究.
结论:
- LINAC4和Nuclotron适用于临床前的UHDR和FLASH放射生物研究.
- 这些加速器满足了FLASH效应系统体外研究的物理先决条件.
- 能够在临床环境之外进行研究,探索剂量值,组织反应和FLASH机制.
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