老龄化不会影响OCT和临床或MRI结果测量之间的关系
S Kaçar1, Julia R Jelgerhuis2, J Killestein1
1MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC Location VUmc, Amsterdam, the Netherlands.
Multiple sclerosis and related disorders
|February 12, 2026
概括
视网膜神经纤维层 (RNFL) 和质细胞内状层 (GCIPL) 厚度与MRI和多发性硬化症 (MS) 的临床结果显著相关. 这些关联在MS患者中保持一致,并且在很大程度上独立于年龄.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
背景情况:
- 多发性硬化症 (MS) 神经退行与正常的衰老过程重叠.
- 在MS研究中的统计年龄校正可能无法完全将疾病特异性变化与衰老影响隔离开来.
研究的目的:
- 调查年龄对视网膜测量 (RNFL,GCIPL) 和MRI/MS的临床结果之间的关系的影响.
- 为了确定与年龄相关的变化是否会影响视网膜结构和多发性硬化症标志物之间的关联.
主要方法:
- 两个MS队列的比较:一个与出生年份匹配的队列 (Project Y) 和一个年龄异质的队列 (PrograMS).
- 利用多级线性回归模型来评估横截面关联,并根据相关的共变量进行调整.
- 在异质队列分析中将年龄作为共变量纳入.
主要成果:
- 在两个队列中,在RNFL/GCIPL厚度和MRI测量 (大脑,白质,病变,丘脑体积) 和临床结果 (EDSS,SDMT) 之间发现了显著的关联.
- 效应的大小各不相同,但关联的方向在所有队列中保持一致.
- 包括年龄作为共同变量并没有显著改变视网膜测量和MRI/临床结果之间的观察到的关联.
结论:
- 视网膜神经纤维层 (RNFL) 和质细胞内状层 (GCIPL) 厚度显示出与MS中关键的MRI和临床指标具有显著的横截面关联.
- 这些协会在不同MS队伍中表现出一致的指导性.
- 视网膜测量和MS结果之间的观察到的关系似乎在很大程度上独立于年龄.
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