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暴露于会通过氧化应激和炎症加速肉养殖者的卵巢衰老

Peng Xu¹, Tong Xing¹, Lin Zhang¹

¹College of Animal Science and Technology, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, Nanjing 210095, PR China.

Animal reproduction science

|February 12, 2026

概括

暴露于会通过增加氧化应激和炎症,加速肉养殖者的卵巢衰老. 这项研究揭示了.

科学领域:

环境毒理学环境毒理学
生殖生物学生殖生物学
鸟类科学鸟类科学

背景情况:

(Cd) 是一种有毒的环境污染物,已知对生殖有影响.
对于Cd对肉养殖者的卵巢衰老的具体影响尚不清楚.

研究的目的:

调查慢性暴露对肉养殖者卵巢老化的影响.
阐明诱导的卵巢衰老的潜在机制.

主要方法:

在 brojiler繁殖者中建立了10周暴露模型.
产卵性能,卵质量,血清生物化学参数 (AST,ALT,TG),卵巢组织病理,氧化应激标志物 (4-HNE,MDA,T-AOC,SOD,GSH-Px),炎症基因表达 (IFN-γ,IL-8,IL-17,NF-κB),细胞亡 (TUNEL,Bax,caspases) 和衰老标志物 (P21,P16,γ-H2AX,SIRT1,SIRT6) 的评估.

主要成果:

暴露会影响产卵性能和蛋质量.
它提高了血清AST和ALT,降低了TG,降低了卵巢肌体重量,并损坏了卵巢结构,减少了卵泡数量.
诱导了卵巢氧化应激,炎症,增加了亡,并通过改变关键基因和蛋白质表达来促进细胞衰老.

结论:

暴露于会加速肉养殖者的卵巢衰老.
这种衰老过程是由诱导的氧化应激和炎症驱动的.
这些发现表明,诱导的生殖毒性减轻潜在的治疗目标.

关键词:

brojler 养殖者 brojler 养殖者 brojler 养殖者和是最重要的元素.这是一种炎症炎症炎症炎症.卵巢衰老卵巢衰老卵巢衰老氧化应激是一种氧化应激.

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