多价值疫苗接种方案对Bos indicus牛肉雌性动物生殖效率的影响
Rodrigo de Morais1, Fúlvio Picanço Florenzano2, Adryele Araujo Borges Lima3
1Graduate Program in Animal Reproduction in the Amazon (ReproAmazon), Institute of Animal Health and Production (ISPA), Federal Rural University of the Amazon (UFRA), Belém, PA, Brazil; Federal Institute of Education, Science and Technology of Pará (IFPA), Marabá, PA, Brazil.
Animal reproduction science
|February 12, 2026
概括
这项研究评估了一种用于肉牛生殖健康的多价值疫苗. 虽然最初的生育率没有变化,但接种疫苗的奶牛在第二次授精后的怀孕率有所改善,怀孕流产率有所降低,这表明暴露群体的安全性和潜在益处.
科学领域:
- 兽医免疫学 兽医免疫学
- 生殖生物学 生殖生物学
- 牛的健康管理
背景情况:
- 牛肉牛群的繁殖性疾病,包括牛疹病毒1 (BoHV-1),牛病毒性腹病毒 (BVDV),Leptospira spp.和Campylobacter胎儿,显著影响牛群的生产力.
- 这些药物的高疫苗接种前血清流行率表明,在研究的Bos indicus种群中,自然暴露很普遍.
- 评估多价值生殖疫苗接种计划的有效性对于改善群体生殖表现至关重要.
研究的目的:
- 评估多价值生殖疫苗接种计划对肉牛和母牛生殖表现的影响.
- 确定在接受定时人工授精 (TAI) 的Bos indicus群体中对BoHV-1,BoHV-5,BVDV-1,BVDV-2,Leptospira spp.和C.胎儿的疫苗接种的安全性和有效性.
主要方法:
- 总共有1217头肉牛和小牛被连续两次接受TAI协议.
- 接种疫苗包括TAI前21-30天的初始剂量,第0天的增强剂,以及随后的Leptospira spp.增强剂. 在怀孕期间.
- 每个AI的怀孕 (P/AI) 通过超声波和触摸来评估,并监测到出生时的分娩率.
主要成果:
- 在接种疫苗和对照组之间的第一个TAI后,没有观察到P/AI的显著差异.
- 在第二次TAI之后,接种疫苗的动物在120天后表现出更高的P/AI (P=0.03) 和在30至120天之间减少妊娠损失.
- 疫苗接种前的高抗体标位表明,在群体内,有大量的先前暴露于向病原体.
结论:
- 多价值无活化生殖疫苗对Bos indicus肉牛是安全的.
- 接种疫苗可能会增强自然暴露于繁殖病原体的高水平的群体的免疫稳定性.
- 疫苗对立即生育能力的影响似乎有限,特别是在具有先前免疫力的人群中,但在后来的生殖阶段显示出好处.
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