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Updated: Feb 14, 2026

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在B细胞枯竭中持续的帕尔沃病毒B19DNAemia:在多发性硬化症和相关疾病中对计划生育的影响
Lorenz Karnbrock1, Marina Herwerth2, Guido Vincent Bloemberg3
1Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
Journal of the neurological sciences
|February 12, 2026
概括
多发性硬化症 (MS) 和相关疾病的B细胞枯竭增加了感染风险. 在这些患者中,持久的帕沃病毒B19 (B19V) 感染可能会导致严重的并发症,包括不良妊娠结果.
科学领域:
- 神经免疫学 神经免疫学
- 病毒学 病毒学
- 免疫抑制是一种免疫抑制.
背景情况:
- B细胞枯竭是多发性硬化症 (MS),神经omyelitis optica光谱障碍 (NMOSD) 和髓寡细胞糖蛋白相关疾病 (MOGAD) 的关键治疗方法.
- 由于B细胞枯竭导致的免疫抑制会增加病毒和细菌感染的风险.
- 最近的一次帕尔沃病毒B19 (B19V) 疫情突出显示了B细胞枯竭患者持续的B19V感染.
研究的目的:
- 研究在接受B细胞枯竭治疗的MS和相关神经免疫学疾病患者中持续的B19V感染的临床影响.
- 了解与这种脆弱人群中B19V暴露相关的风险.
主要方法:
- 在2013-2023年期间和2024年B19V爆发期间治疗的神经免疫疾病患者的回顾性观察研究.
- 纳入标准:B细胞枯竭治疗和确诊的B19V感染.
- 收集的数据:临床表现,实验室发现和治疗反应.
主要成果:
- 三名B细胞枯竭患者 (两名RRMS在ocrelizumab,一个MOGAD在rituximab) 已证实B19V感染.
- 两名患者呈现第五种疾病症状 (中性贫血,贫血,肝酶升高);一名孕妇患者有轻度症状但胎儿贫血.
- 静脉注射免疫球蛋白 (IVIG) 改善了症状,但所有患者都保持了持久的B19V DNAemia.
结论:
- 像B19V这样的传染性儿童疾病对接受B细胞枯竭治疗的患者构成重大风险.
- 这些风险包括严重的并发症和潜在的不良妊娠结果.
- 这些发现强调了监测和管理B19V在免疫受损个体的重要性.
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