通过皮肤进行的电神经刺激改善了患有多发性硬化症的疲劳患者的步行:一项随机对照试验
Nikki Dreijer1, Leda B Maffei1, Menno P Veldman2
1Department of Biomedical Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; MS Center Noord Nederland, Groningen, the Netherlands.
Annals of physical and rehabilitation medicine
|February 12, 2026
概括
在休息期间应用的穿皮电神经刺激 (TENS) 改善了多发性硬化症 (pwMS) 患者的行走性能. 与假刺激相比,TENS并没有显著改善疲劳或感知到的行走限制.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 多发性硬化症 (pwMS) 严重影响日常生活,原因是步行困难和疲劳.
- 通过传感运动通路探索诸如皮肤间电神经刺激 (TENS) 等非药理学策略,以增强运动功能.
- 了解TENS对pwMS患者的移动性和疲劳的影响对于改善生活质量至关重要.
研究的目的:
- 评估TENS对 pwMS 步行表现和疲劳的疗效.
- 为了比较休息期间应用的TENS与与假刺激对抗的同时炼.
- 确定TENS是否为pwMS的运动障碍提供了优质的非药物干预.
主要方法:
- 一个随机的,双盲的,假的受控试验,涉及80 pwMS疲劳和行走困难.
- 参与者被分配到仅TENS,TENS加运动,假刺激或假加运动组.
- 干预包括12次10分钟的4周的会议,在基线,干预后和随访时评估结果.
主要成果:
- 与假刺激相比,在休息期间应用的TENS显著改善了步行距离 (6分钟步行测试).
- 在TENS组中,更高比例的参与者在步行距离方面取得了临床上有意义的改善.
- 没有观察到主观疲劳指标或分组之间感知到的行走限制的显著差异.
结论:
- 休息TENS显示了增强 pwMS 步行表现的潜力.
- 在运动期间应用的TENS与假的相比,对行走性能没有显著的好处.
- 需要进一步的研究来阐明TENS对运动功能的影响背后的神经生理机制.
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