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Updated: Feb 14, 2026

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外源性黑激素通过改善脂质代谢来缓解热应激诱导的代谢减缓,影响肉生长,从而改善脂质代谢
Fei Song1, Binglin Wang1, Xin Kang1
1College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Journal of thermal biology
|February 12, 2026
概括
补充黑素 (MT) 通过调节脂质新陈代谢,在热应激下改善肉的生长. 最佳剂量为1.0 mg/kg,可增强脂肪酸氧化,减少脂质合成,减轻热应激效应.
科学领域:
- 动物科学动物科学
- 营养生物化学 营养生物化学
- 禽类生理学 禽类生理学
背景情况:
- 热应激 (HS) 通过诱导代谢减缓,对牲畜和家禽的生长产生负面影响.
- 脂质代谢障碍是HS的重要后果,影响动物的整体健康和生产力.
- 黑色素 (MT) 是一种具有潜在抗氧化和代谢调节功能的激素.
研究的目的:
- 调查黑激素 (MT) 在减轻肉中热应激诱导的脂质代谢障碍方面的疗效.
- 阐明MT缓解HS相关的代谢减缓和生长障碍的潜在分子机制.
- 确定最佳的MT剂量,以改善热应激下 brojlers的脂质代谢和生长性能.
主要方法:
- 实体研究涉及60只肉,分为控制,HS和不同的MT干预组 (0.5,1.0,2.0毫克/公斤).
- 血清脂质概况 (T-CHO,TG,GLU,LDL) 的生物化学分析和肝脂沉积和氧化损伤的评估.
- 网络药理学分析以确定MT调节的信号通路,然后进行RT-qPCR以验证基因表达 (AMPK/PPARα,SREBP1/FASN).
主要成果:
- 补充黑素显著改善了暴露于热应激的 brojlers 的生长性能.
- 与HS组相比,MT干预降低了血清脂水平,肝脂沉积和氧化损伤.
- MT激活了AMPK/PPARα信号通路,促进脂肪酸氧化,并抑制了SREBP1/FASN通路,减少了脂质合成.
结论:
- 黑色素有效地减轻肉中热应激诱导的脂质代谢障碍.
- 干预的最佳MT剂量为1.0mg/kg体重,显示了脂质代谢和生长的显著改善.
- MT通过通过AMPK/PPARα和SREBP1/FASN通路对脂质代谢的多目标调节来发挥其有益作用.
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