在线解估计在侵入性激光热疗法期间生物组织中的温度场
Zhaohui Mao1, Hong Chen2, Guangjun Wang2
1School of Energy and Power Engineering, Chongqing University, Chongqing, 400044, China.
Journal of thermal biology
|February 12, 2026
概括
这项研究引入了一种新的脱估计方法,用于在侵入性激光诱导热疗法 (LITT) 期间精确的在线温度场监测. 这种方法提高了关键瘤区域实时温度估计的计算效率.
科学领域:
- 生物医学工程 生物医学工程
- 医学物理 医学物理
- 计算生物学 计算生物学
背景情况:
- 侵入性激光诱导热疗法 (LITT) 是一种对深层瘤的最小侵入性治疗方法.
- 准确的在线温度场估计对于LITT开发和安全应用至关重要.
- 目前的状态估计方法在LITT中与分离的温度场估计作斗争.
研究的目的:
- 在侵袭性LITT.期间开发生物组织温度场的在线脱估计方案.
- 在LITT温度监测中克服合状态空间模型的局限性.
- 为LITT程序提供高效可靠的技术支持.
主要方法:
- 构建一个最佳估计模型和一个时空相关模型.
- 实施关键温度点的在线分离估计.
- 使用实验数据验证生物模型.
- 数字模拟分析时间域,噪声和模型不匹配的影响.
主要成果:
- 拟议的脱估计方案有效地估计了LITT期间的组织温度场.
- 该方法在计算效率方面具有显著的优势,与用于特定区域估计的标准卡尔曼波器相比.
- 模型可靠性得到了验证,并分析了各种因素对估计的影响.
结论:
- 开发的在线脱估计方案为LITT温度场监测提供了可靠的解决方案.
- 这种方法提高了计算效率,使其适合于瘤区域的实时温度估计.
- 这项研究为推进LITT技术提供了至关重要的技术支持.
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