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Updated: Feb 14, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
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Published on: July 20, 2016

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系统的囊素扫描识别了瘤性KRAS中可用药物的口袋

Laurens M van Tienen1, Shadwa Bayoumi2, Khaja Muneeruddin3

  • 1The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Cell chemical biology
|February 12, 2026
PubMed
概括

可访问口袋的氨酸映射 (CysMAP) 识别了蛋白质中的新药标. 这种方法在KRAS (G12D) 变体中发现了新的结合口袋,为具有挑战性的目标推进了治疗开发.

关键词:
克拉斯 (Kras) 是一个国家.共价化合物是一种共价化合物.囊素扫描扫描 囊素扫描完整的质谱学完整的质谱学.查检查 查检查 查检查 查检查

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