成人肥胖和严重感染的风险:一项多队列研究,估计了全球负担
Solja T Nyberg1, Philipp Frank2, Sara Ahmadi-Abhari3
1Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Finnish Institute of Occupational Health, Helsinki, Finland.
Lancet (London, England)
|February 12, 2026
概括
成年人肥胖显著增加了严重感染,住院和死亡的风险. 这种可预防的风险因素与全球大约十分之一的感染相关死亡有关.
科学领域:
- 传染病 流行病学 流行病学
- 公共卫生风险因素 公共卫生风险因素
- 肥胖问题研究研究
背景情况:
- 关于与成年人肥胖相关的传染病全谱的证据有限.
- 肥胖是一种普遍且可预防的风险因素,具有潜在的广泛健康影响.
- 了解肥胖对传染病的影响对于公共卫生战略至关重要.
研究的目的:
- 调查成年肥胖与各种传染病的发病率,住院和死亡率之间的联系.
- 估计肥胖对传染病结果的全球和区域影响.
- 分析COVID-19大流行之前,期间和之后的肥胖引起的感染趋势.
主要方法:
- 多队列研究利用来自芬兰队列和英国生物库的综合数据.
- 基于身体质量指数 (BMI) 的参与者的分类:健康体重,超重和肥胖类 I-III.
- 通过传染病住院和死亡的国家登记处进行跟进,并进行影响建模.
主要成果:
- 与健康体重个体相比,患有III级肥胖症的个体面临感染相关住院和死亡的风险是健康体重个体的三倍.
- 在任何肥胖 (I-III类) 个体中,观察到严重感染 (致命或非致命) 的综合危险比为1.7.
- 据估计,与肥胖有关的感染相关死亡率为8.6% (2018年),15.0% (2021年) 和10.8% (2023年).
结论:
- 成人肥胖是感染相关住院和死亡的重要风险因素,涉及各种病原体和人群.
- 全球约有10%的感染相关死亡可能归因于肥胖.
- 解决肥胖问题对于减少全球传染病负担至关重要.
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