信号劫持者:瘤如何选择化学,电气和机械线索以壮成长
Yong-Fei Wang1, Si-Yuan Wang1, Zhuo-Ying He1
1Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China.
Biochimica et biophysica acta. Reviews on cancer
|February 12, 2026
概括
瘤劫持化学,电气和机械信号,以创造一个支持性的微环境. 破坏这种"信号劫持"网络提供了一种克服癌症治疗耐药性的新策略.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 蜂通信 蜂通信
背景情况:
- 瘤通过操纵化学,电气和机械信号来在敌对的微环境中壮成长.
- 一个协调的,三维的信号网络允许瘤重塑其生态系统以求生存.
研究的目的:
- 引入一个统一的"信号劫持"框架,以了解瘤生存机制.
- 审查瘤如何利用和重编程瘤微环境中的细胞通信.
主要方法:
- 关于瘤信号通路的现有文献的审查.
- 分析瘤利用的化学,生物电和机械通信机制.
- 检查针对瘤传播的治疗策略.
主要成果:
- 瘤劫持化学信号 (代谢物,细胞因子),生物电信号 (离子梯度,间隙连接) 和机械信号 (ECM,细胞间张力).
- 这种劫持重新编程细胞和遗传景观,促进瘤存活和免疫抑制.
- 治疗策略包括化学拦截,生物电再校准和机械干预.
结论:
- "信号劫持"模式将癌症重新定义为一种争夺沟通控制的战斗.
- 恢复信号稳定,而不仅仅是细胞减小,对于克服治疗耐药性至关重要.
- 向瘤通信网络是一个有前途的治疗途径.
相关概念视频
Chemical Signaling in the Endocrine System
7.4K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
7.4K
Mechanical and Chemical Digestion in the Small Intestine
3.5K
The small intestine plays a crucial role in our digestive system, performing both mechanical and chemical digestion.
Mechanical digestion in the small intestine involves movements such as segmentations and migrating motility complexes (MMCs), primarily controlled by the myenteric plexus. Segmentations are localized contractions occurring in areas of the intestine distended by chyme—a mixture of partially digested food. These contractions mix chyme with digestive juices, facilitating...
Mechanical digestion in the small intestine involves movements such as segmentations and migrating motility complexes (MMCs), primarily controlled by the myenteric plexus. Segmentations are localized contractions occurring in areas of the intestine distended by chyme—a mixture of partially digested food. These contractions mix chyme with digestive juices, facilitating...
3.5K
Non-Verbal Cues
344
Non-verbal communication extends beyond gestures and facial expressions to include vocal elements known as paralanguage. Paralanguage consists of non-verbal vocal cues such as pitch, loudness, speech rate, pauses, and non-verbal vocalizations like laughter, sighs, and moans. These elements not only accompany speech but also provide critical emotional and contextual information.The Role of Paralanguage in CommunicationParalanguage adds depth to spoken language by conveying emotions and...
344
Synaptic Signaling
79.8K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
79.8K
Bacterial Signaling
41.3K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
41.3K
Reaction Mechanisms
31.2K
Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
31.2K


