在生育护理中的女性生殖微生物群
Samiya Dash1, Dong Zhao2, Ina Schuppe-Koistinen1
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17165 Stockholm, Sweden.
Fertility and sterility
|February 12, 2026
概括
评估女性生殖微生物组对于理解无法解释的不孕症至关重要. 本次审查评估了当前的诊断方法,突出了改善生育护理的研究和临床应用之间的差距.
科学领域:
- 生殖医学 生殖医学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 女性生殖微生物组显著影响生殖健康和生育能力.
- 传统的不孕症评估往往会让很大一部分病例无法解释.
- 微生物因素越来越被认为是生育结果的关键因素.
研究的目的:
- 批判性地评估评估女性生殖微生物组的方法.
- 分析当前微生物组测试平台的临床有效性和实用性.
- 确定差距,并提出临床实施的标准.
主要方法:
- 基于传统文化和当代分子方法的系统审查.
- 对诸如Nugent评分,qPCR,16S rRNA测序和猎枪元基因组学等技术的诊断性能和临床实用性的评估.
- 评估微生物组分析的多omics集成.
主要成果:
- 研究方法与临床可行的诊断之间存在重大差距.
- 发现缺乏标准化协议,细菌负载报告不一致,对生殖结果的验证有限.
- 目前的微生物组测试平台显示出可变的临床有效性和实用性.
结论:
- 标准化和验证是必要的,以弥合微生物组诊断领域的研究和临床实践之间的差距.
- 提出了基于证据的标准,用于在生育护理中选择适当的诊断方法.
- 新兴技术,如多omics,有望为未来的微生物组评估在生育治疗.
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