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相关概念视频

Overview of DNA Repair02:25

Overview of DNA Repair

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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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相关实验视频

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A New Murine Model of Endovascular Aortic Aneurysm Repair
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在B型大动脉剖析中,内血管修复期间的内密-内密内吸收.

Xiaolang Jiang1, Weiguo Fu2, Weifeng Lu3

  • 1Institute of Vascular Surgery, Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
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概括
此摘要是机器生成的。

支架移植诱导的大动脉内密-内密内 (SAoII) 是B型大动脉剖析 (TBAD) 的胸内血管大动脉修复 (TEVAR) 的罕见并发症. 确定SAoII的关键成像特征对于成功的内血管管理和改善患者治疗结果至关重要.

关键词:
阳性并发症 阳性并发症支架移植诱导了大动脉内密-内密内异常发生.胸内血管大动脉修复乙型大动脉剖析

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科学领域:

  • 心血管外科心血管外科
  • 干预性放射学 干预性放射学
  • 医疗成像医学成像

背景情况:

  • 支架移植诱导的大动脉内密-内密内 (SAoII) 是一种罕见但潜在的灾难性并发症,在胸内血管大动脉修复 (TEVAR) 期间用于B型大动脉剖析 (TBAD).
  • 准确识别SAoII的成像特征对于及时有效的管理至关重要,以防止不良结果.

研究的目的:

  • 报告SAoII的可靠成像特征.
  • 为了改善治疗TBAD的TEVAR期间避免和管理这种并发症.

主要方法:

  • 从2014年1月到2022年12月接受TBADTEVAR治疗的患者的回顾性多中心观察分析.
  • 定义SAoII是由于TEVAR而导致的大动脉内脏的程序内破坏.
  • 对SAoII的成像特征和管理策略的总结.

主要成果:

  • 在接受TEVAR治疗TBAD的1643名患者中,SAoII在20名患者 (1.2%) 观察到.
  • 关键的成像特征包括浮动内移植 (85%),内脏层的内脏异位 (65%),以及内脏/线/输送系统的移位 (40%).
  • 在支架移植部署后,SAoII最常发生 (60%). 所有患者都通过额外的支架移植成功管理,在51.5个月的中位随访期间没有发生主动脉相关死亡.

结论:

  • SAoII是TEVAR治疗TBAD的罕见,可能致命的阳性并发症.
  • 以及时准确识别成像特征为指导的内血管干预措施,对管理SAoII.有效.
  • 识别特定的成像发现对于成功治疗这种并发症至关重要.