Tet(X4) - 在台湾生产大肠杆菌分离物
Wen-Chun Huang1, Yu-Tsung Huang2, Wen-Chien Ko3
1Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Journal of global antimicrobial resistance
|February 12, 2026
概括
在大肠杆菌中发现的第一个tigecycline耐药性基因tet ((X4),是在台湾发现的,在可移动的等离子体上携带在对carbapenem敏感的菌株中. 这凸显了对抗生素耐药性基因持续监测的必要性.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 等离子体介导的tet(X4) 具有高水平的tigecycline耐药性,并首次在中国被发现.
- 大肠杆菌 (E. coli) 作为这种耐药性基因的重要储存库.
- 在这项研究之前,台湾没有报告过大肠杆菌中tet(X4) 的确诊病例.
研究的目的:
- 调查来自台湾的抗环素耐药大肠杆菌分离物中的tet(X4) 的存在和特征.
- 为了识别携带tet(X4) 的遗传元素和质粒.
- 了解tet的进化分歧和水平基因转移的潜力X4).
主要方法:
- 分析了2015-2022年期间在台湾收集的81种耐蒂芝林耐药大肠杆菌分离物.
- 36个分离物的全基因组测序以确定耐药性机制.
- 流动性遗传元素的等离子体表征和识别.
主要成果:
- 两种大肠杆菌分离物 (2.5%) 在新型塑体pEC1360-1和pEC1638-1上藏着tet(X4).
- 在移动ISVsa3-estT-tet ((X4) -ISVsa3 (IETI) 元素中发现了tet(X4) 基因.
- Tet(X4) 仅在对卡巴胺敏感菌株中检测到,并且位于不同的Inc型等离子体上,与之前报告的中国菌株不同.
结论:
- 这项研究证实了台湾首次出现tet(X4) 阳性大肠杆菌,特别是对卡巴胺敏感的单独体.
- 鉴定了携带tet(X4) 的新型移动等离子体,强调了横向基因转移的风险.
- 持续监测tet(X) 基因和其他关键抗生素耐药性机制至关重要,以防止进一步传播.
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