心脏代谢风险因素损害了与酒精有关的肝脏疾病的补偿和生存
Kelly Torosian1, Luis Antonio Díaz2, Kaleb Tesfai3
1Division of Gastroenterology and Hepatology, University of California San Diego, San Diego, CA, USA.
糖尿病和肥胖等心脏代谢风险因素 (CMRF) 降低了等待肝移植 (LT) 的酒精相关肝病 (ALD) 患者的肝脏补偿和存活率. 解决这些因素对于管理ALD患者至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 与酒精相关的肝病 (ALD) 患者经常出现心脏代谢风险因素 (CMRF).
- 在等待肝移植 (LT) 的ALD患者中,CMRF对临床结果的影响尚未完全理解.
- 这项研究调查了CMRFs与早期LT转诊的ALD患者的肝脏补偿和存活率之间的关联.
研究的目的:
- 评估CMRFs对ALD患者肝脏补偿的影响.
- 为了评估CMRFs对ALD患者存活率的影响,提到了早期LT.
- 确定影响ALD结果的特定CMRF.
主要方法:
- 一个多中心的,对617名ALD患者进行回顾性队列研究,评估了早期LT.
- 收集的数据包括体重指数 (BMI),2型糖尿病 (T2DM),高血压 (HTN) 和高脂血症 (HLD).
- 分析的结果是肝脏补偿和没有LT的存活率.
主要成果:
- 50% (307/617) 的患者被拒绝接受LT或从等待列表中删除.
- 在LT转诊后6个月,12个月和24个月,CMRF与肝脏补偿的降低有关 (p<0.01).
- 2型糖尿病 (T2DM) 和高BMI显著影响了没有LT的补偿和生存 (sHR 0.97,p<0.01).
结论:
- 主要的CMRFs,特别是T2DM和高BMI,与ALD患者的补偿和存活率较差有关,这些患者被认为是早期LT.
- 这些发现强调了在ALD患者中评估CMRF的重要性.
- 在评估ALD患者的补偿潜力和移植必要性时,考虑CMRF至关重要.
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