重建性片手术后的头部放射治疗:多中心XFLAP1研究的结果
Di Rito Alessia1, Blache Alice2, Preudhomme Renaud3
1Radiation Oncology Unit, Hospital "Mons. A.R. Dimiccoli" - Barletta, Italy.
概括
头癌局部复发 (HNC) 片重建在片体内很罕见. 将放射治疗目标集中在本地组织-接处可能会减少副作用.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 头癌 (HNC) 重建性手术在术后目标划分方面存在挑战.
- 关于在放射治疗计划中是否包括整个片或专注于本地组织-片结合,存在争论.
研究的目的:
- 量化HNC患者相对于片的复发模式.
- 要总结当前的实践,毒性和片重建和放射治疗后的功能结果.
主要方法:
- 对XFLAP1队列 (2018-2023) 的回顾性分析,包括355名HNC患者.
- 患者接受了瘤切除与片重建和术后放射治疗 (PORT) ±化疗.
- 竞争风险和卡普兰-梅尔方法被用于分析局域性复发 (LRR),转移和整体存活率 (OS).
主要成果:
- 在67%的案例中使用了自由,在33%的案例中使用了区域脚式.
- 只有1%的复发 (3/355) 发生在体内;大多数局部故障发生在本地组织-接处.
- 两年累计发病率为LRR的15.8%,转移的16.7%;两年的OS为74.6%.
结论:
- 在HNC患者中,体中心的复发不常见.
- 目前的数据表明,应将临床目标体积 (CTV) 集中在原生组织-接处.
- 这种方法可能有助于限制与治疗相关的发病率,等待未来的验证.
相关概念视频
Arteries of the Head and Neck
3.6K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
3.6K
Veins of Head and Neck
5.8K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
5.8K
Muscles of the Anterior Neck
4.9K
The anterior neck muscles are the group of muscles covering the front part of the neck. These muscles are classified into three subgroups. The first one is the superficial muscles, the most visible muscles in the front of the neck. It includes the platysma and sternocleidomastoid. The second group is the suprahyoid muscles, located above the hyoid bone. This group comprises the digastric, mylohyoid, geniohyoid, and stylohyoid. Lastly, the infrahyoid muscles are found below the hyoid bone and...
4.9K
Muscles that Move the Head
6.1K
The muscles that move the head are a dynamic and complex group of structures that work together to facilitate a wide range of head movements, including rotation, flexion, extension, and lateral bending.
The bilateral sternocleidomastoid, or SCM, and the suprahyoid and infrahyoid muscles are significant head flexors. The SCM muscles originate at the sternum and clavicle and attach to the mastoid process of the temporal bone. The SCM contracts bilaterally to bend the head forward, whereas...
The bilateral sternocleidomastoid, or SCM, and the suprahyoid and infrahyoid muscles are significant head flexors. The SCM muscles originate at the sternum and clavicle and attach to the mastoid process of the temporal bone. The SCM contracts bilaterally to bend the head forward, whereas...
6.1K
Reconstruction of Signal using Interpolation
746
Signal processing techniques are essential for accurately converting continuous signals to digital formats and vice versa. When a continuous signal is sampled with a period T, the resulting sampled signal exhibits replicas of the original spectrum in the frequency domain, spaced at intervals equal to the sampling frequency. To handle this sampled signal, a zero-order hold method can be applied, which creates a piecewise constant signal by retaining each sample's value until the next...
746
Electron Microscope Tomography and Single-particle Reconstruction
2.9K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
2.9K


