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在实验性风湿性关节炎中,renin-angiotensin系统和neuropilin-1途径之间的潜在交叉路口
Nourhan E Shahin1, Nesrine S El-Mezayen2, Mahmoud M Khattab3
1Health Affairs Directorate in Alexandria, Egypt.
概括
使用瓦尔萨坦或拉米普利尔的宁-血管酶系统 (RAS) 阻塞,通过调节神经皮林-1 (NRP-1) 信号通路,在风湿性关节炎 (RA) 鼠标模型中有效降低炎症并保护关节结构.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 涉及持续的突炎,血管生成和关节破坏.
- 氨酸- ангиотензин系统 (RAS) 和神经平素-1 (NRP-1) 参与了RA的发病.
- 了解RAS和NRP-1之间的相互作用对于开发新的RA治疗方法至关重要.
研究的目的:
- 在RA的老鼠模型中研究RAS和NRP-1信号之间的机械联系.
- 评估RAS抗剂 (瓦尔萨坦,拉米普利尔) 和甲状腺素对RA病变的作用.
- 评估对炎症媒介,血管重塑和关节完整性的影响.
主要方法:
- 用完整的弗洛恩德辅助剂诱导了一种鼠类RA模型.
- 动物接受了瓦尔萨坦 (AT-1R抗剂),拉米普利 (ACE抑制剂) 或甲铁酸盐的治疗.
- 分析了NRP-1表达,联体结合,下游信号蛋白 (RhoA,p-ERK),炎症标记物和骨再吸收标记物.
- 组织病理学和扫描电子显微镜 (SEM) 评估了关节的完整性.
主要成果:
- 瓦尔萨坦和拉米普里尔显著调节了NRP-1信号,影响了联体受体相互作用和下游介质.
- 拉斯阻断减少了全身炎症调解剂 (抗CCP,TNF-α,IL-1β) 和RANKL.
- 组织病理学和SEM分析显示,治疗组的骨和软骨结构得到保存.
结论:
- 通过瓦尔萨坦或拉米普利尔阻断RAS,通过调节NRP-1轴在RA中显示出冠状动脉保护和抗炎作用.
- 在RA的发病过程中,RAS和NRP-1通路之间存在机械交叉交谈.
- 针对RAS-NRP-1轴提供了一个新的辅助疗法在类风湿性关节炎管理的潜在策略.
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