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Updated: Feb 14, 2026

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基于昆素的UCHL5抑制剂作为20S抑制之外的下一代蛋白质酶向抗癌剂

Tae-Hee Han1, Joohan Lee2, Joo-Young Im3

  • 1Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea National University of Science and Technology (UST), Daejeon 34113, South Korea.

Journal of advanced research
|February 12, 2026
PubMed
概括

一种新型的昆素衍生物DK-7可以选择性地抑制UCHL5,一种蛋白酶组分. 这种化合物有效触发癌细胞亡并克服博特佐米布耐药性,显示出固体瘤治疗的前景.

关键词:
19S 蛋白质索二维基因酶 UCHL55博尔特佐米布的耐药性蛋白质酶体抑制剂 蛋白质酶体抑制剂基于昆素的小分子DK-7乌比基蛋白质酶体系统

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