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微粒对抗莱什曼病:改造药物输送系统的进展,挑战和前景
Laiene Antunes Alves1, Soraia de Oliveira Simião1, Laís Salvador do Amaral2
1Centro de Estudos em Biofarmácia, Departamento de Farmácia, Universidade Federal do Paraná, Curitiba, Brasil.
Microbial pathogenesis
|February 12, 2026
概括
微粒提供了一个有前途的新方法来治疗莱什曼病,通过改善药物输送和减少毒性. 这一策略提高了这种被忽视的热带疾病的治疗效率.
科学领域:
- 制药科学 制药科学
- 寄生虫学的寄生虫学
- 药物输送系统 药物输送系统
背景情况:
- 莱什曼病影响全球数以百万计的人,目前的治疗方法面临毒性,成本和耐药性问题.
- 创新的治疗策略对于管理这种被忽视的热带疾病至关重要.
研究的目的:
- 审查和综合治疗莱什曼病的微粒子配方的证据.
- 为了评估基于微粒的药物输送在Leishmania感染中的有效性和安全性.
主要方法:
- 按照乔安娜·布里格斯研究所的方法和PRISMA-ScR指南进行系统审查.
- 在PubMed,Scopus和Web of Science中进行的针对Leishmania spp.的微粒子配方的搜索.
- 对36篇文章的分析包括专注于药物封装,聚合物,注射途径和毒性.
主要成果:
- 氨酸B封装 (21.6%的研究) 显著降低了其毒性,允许更安全的更高剂量.
- 聚乳酸-联合甘油酸 (PLGA) 是最常见的聚合物 (38.9%),增强了巨细胞的吸收.
- 腹腔内服 (92.8%) 占主导地位,但微粒大小均性的挑战表明口服/局部途径的潜力.
结论:
- 微粒物代表了莱什曼病治疗的可行替代品,提高了药物的疗效,减少了不良影响.
- 这种方法为开发先进的药物配方提供了新的视角,以克服当前治疗方法的局限性.
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