环境丰富增强了雄性小鼠在筑巢行为中的个体间变异性
Misa Iwasaki1, Shun Kurokawa1, Hodaka Suzuki2
1College of Agriculture, Ibaraki University, Ami-machi, Ibaraki 300-0393, Japan.
Physiology & behavior
|February 12, 2026
概括
环境丰富 (EE) 增加了小鼠的行为多样性,影响了筑巢和类似焦虑的行为. 这种增强的变异性可能有助于识别类似抑郁症的表型.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 生理学 生理学 生理学
背景情况:
- 众所周知,环境丰富 (EE) 影响动物的大脑功能和行为.
- 了解短期EE的具体影响对于解释动物模型研究至关重要.
研究的目的:
- 研究短期EE对雄性C57BL/6J小鼠的行为和生理影响.
- 评估EE对筑巢,焦虑类行为和生理参数的影响.
主要方法:
- 年轻的雄性C57BL/6J小鼠在EE或标准环境 (SE) 条件下安置了两周.
- 行为测试包括筑巢,开放场地测试,升高加迷宫,糖糖偏好和尾部悬浮测试.
- 生理学测量包括体重,脏体重和 epididymal 脂肪体重.
主要成果:
- 与SE小鼠相比,EE小鼠在筑巢行为中表现出更大的变化.
- 在开放场地测试中,EE小鼠表现出类似焦虑的行为减少,但在升高加迷宫中焦虑增加.
- 在EE小鼠中,适度的生理变化包括脏重量增加和 epididymal 脂肪重量减少.
结论:
- 短期EE增强了个体间的行为多样性,特别是在目标导向的行为中,如筑巢.
- 筑巢变异性是环境调节和个体差异的敏感指标.
- 由EE引起的行为多样性可能与识别类似抑郁症的表型和理解个人的脆弱性有关.
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