酵母β-葡萄糖对系统性炎症的时间调节和神经保护作用
Wai-Yin Cheng1, Pak-Hei Chan2, Po-Lam Chan3
1Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong; Research Institute for Future Food, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong; Department of Food Science and Nutrition, Faculty of Science, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Carbohydrate polymers
|February 12, 2026
概括
益生菌的多糖,酵母β-葡萄糖和西仁素,可以帮助恢复昼夜节律,减少由系统性炎症引起的神经炎症. 这些益生菌的效果与黑激素和布洛芬相美.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 循环节律障碍与全身炎症和神经炎症有关.
- 研究自然化合物以减轻这些影响至关重要.
研究的目的:
- 评价酵母β-葡萄糖和花仁素对LPS诱导的昼夜节律,肠道微生物群和神经炎症的干扰的影响.
- 为了比较这些效应与黑激素和布洛芬.
主要方法:
- 在C57BL/6J小鼠中使用脂多糖 (LPS) 诱导系统性炎症.
- 分析了时钟基因和细胞因子的日间表达.
- 评估了肠道微生物组成,神经炎症标志物和认知功能.
- 网络分析探索了肠道细菌,代谢物和宿主反应之间的相关性.
主要成果:
- 慢性肺炎破坏了时钟基因和细胞因子的白天节律,导致肝脏和大脑炎症.
- 酵母β-葡萄糖和香草胰岛素调节了这些节律,并降低了神经炎症,类似于黑激素和布洛芬.
- 益生菌逆转了LPS诱导的肠道失调,改善了记忆缺陷,酵母β-葡萄糖显著降低了微质激活.
结论:
- 益生菌多糖,酵母β-葡萄糖和西瓜仁素,在改善昼夜干扰和神经炎症方面显示出显著的潜力.
- 这些益生菌为涉及炎症和破坏生物钟的疾病提供了一种新的治疗途径.
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