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释放功能性食品多糖的潜力:斑马鱼模型作为一个革命性的高通量选平台

Yanjing Liu¹, Sitong Che¹, Jing Xu¹

¹State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, People's Republic of China.

Carbohydrate polymers

|February 12, 2026

概括

斑马鱼为选功能性食品多糖体 (FFPs) 提供了一个具有成本效益的模型. 本次审查强调了它们在评估FPP健康益处方面的有用性,加速了功能性食品的发现.

科学领域:

营养科学营养科学
药理学药理学是指药理学的学科.
毒理学毒理学毒理学

背景情况:

功能性食品多糖 (FFPs) 具有显著的健康益处,但由于昂贵的哺乳动物研究和有限的细胞模型,它们面临发展障碍.
斑马鱼模型为选生物活性化合物提供了一个高通量,全生物体替代方案.
桥梁体外和体外研究对于高效的功能性食品开发至关重要.

研究的目的:

系统地审查斑马鱼作为功能性食品多糖体 (FFPs) 的选平台的应用.
巩固关于斑马鱼在评估FFPs免疫调节,代谢平衡,肠道健康,神经保护和抗瘤活性方面的实用性的证据.
概述一个综合验证管道,以减少FPFs临床开发的风险.

主要方法:

一个系统的框架,用于斑马鱼查的FPFs,包括模型选择和管理路径.
在斑马鱼模型中对FFP的多层次活动评估.
将斑马鱼数据与人类细胞模型和动物研究进行整合以进行验证.

主要成果:

斑马鱼模型在评估各种与健康相关的活动中的FFP方面表现出有效性.
斑马鱼模型提供了一种具有成本效益和高效的FPF选工具.
结合斑马鱼,细胞和动物模型的综合方法增强了FFPs的验证.

结论:

斑马鱼作为一种有价值,具有成本效益的工具,可以加速从生物活性多糖中提取的功能性食品的发现.
像AI和CRISPR这样的新兴技术可以进一步增强斑马鱼中FFPs的机制研究.
斑马鱼模型有效地弥合了FFPs在体外和体内研究之间的差距.

关键词:

生物活性查检查功能性食品中的多糖类.高通量选的高通量选斑马鱼模型模型

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